Liposomal Vitamin D(3) as an Anti-aging Agent for the Skin

Vitamin D(3) is an effective skin protective substance to prevent photoaging. Liposomes were used as a carrier to deliver vitamin D(3) to improve the stability and to enhance the treatment effect of vitamin D(3). The stability of vitamin D(3) liposomes, average cumulative penetration, and retention of vitamin D(3) in the skin were then evaluated and compared with free vitamin D(3). Finally, the treatment effect of vitamin D(3) liposomes in a rat photoaging model was appraised and Haematoxylin-Eosin (H&E) staining was used to assess the histology changes of the skin after vitamin D(3) liposome treatment. The results indicated that liposomes could significantly improve the stability of vitamin D(3). The average skin retention of vitamin D(3) liposomes was 1.65 times that of the vitamin D(3) solution. Vitamin D(3) liposomes could repair the surface morphology of skin in the photoaging model and promote the production of new collagen fibers. Vitamin D(3) liposomes as a potential skin care agent could significantly improve skin appearance and repair damage in the histology of photoaging.