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Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies

Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The...

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Autores principales: Khizer, Zara, Akram, Muhammad R., Sarfraz, Rai M., Nirwan, Jorabar Singh, Farhaj, Samia, Yousaf, Maria, Hussain, Tariq, Lou, Shan, Timmins, Peter, Conway, Barbara R., Ghori, Muhammad Usman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680934/
https://www.ncbi.nlm.nih.gov/pubmed/31261678
http://dx.doi.org/10.3390/polym11071095
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author Khizer, Zara
Akram, Muhammad R.
Sarfraz, Rai M.
Nirwan, Jorabar Singh
Farhaj, Samia
Yousaf, Maria
Hussain, Tariq
Lou, Shan
Timmins, Peter
Conway, Barbara R.
Ghori, Muhammad Usman
author_facet Khizer, Zara
Akram, Muhammad R.
Sarfraz, Rai M.
Nirwan, Jorabar Singh
Farhaj, Samia
Yousaf, Maria
Hussain, Tariq
Lou, Shan
Timmins, Peter
Conway, Barbara R.
Ghori, Muhammad Usman
author_sort Khizer, Zara
collection PubMed
description Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches. Additionally, the morphology of the printed tablets was studied using quantitative 3D surface texture studies and the porosity calculated. Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105%), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higher degree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealed the successful fabrication of extended release matrices.
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spelling pubmed-66809342019-08-09 Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies Khizer, Zara Akram, Muhammad R. Sarfraz, Rai M. Nirwan, Jorabar Singh Farhaj, Samia Yousaf, Maria Hussain, Tariq Lou, Shan Timmins, Peter Conway, Barbara R. Ghori, Muhammad Usman Polymers (Basel) Article Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches. Additionally, the morphology of the printed tablets was studied using quantitative 3D surface texture studies and the porosity calculated. Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105%), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higher degree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealed the successful fabrication of extended release matrices. MDPI 2019-06-28 /pmc/articles/PMC6680934/ /pubmed/31261678 http://dx.doi.org/10.3390/polym11071095 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khizer, Zara
Akram, Muhammad R.
Sarfraz, Rai M.
Nirwan, Jorabar Singh
Farhaj, Samia
Yousaf, Maria
Hussain, Tariq
Lou, Shan
Timmins, Peter
Conway, Barbara R.
Ghori, Muhammad Usman
Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies
title Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies
title_full Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies
title_fullStr Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies
title_full_unstemmed Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies
title_short Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies
title_sort plasticiser-free 3d printed hydrophilic matrices: quantitative 3d surface texture, mechanical, swelling, erosion, drug release and pharmacokinetic studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680934/
https://www.ncbi.nlm.nih.gov/pubmed/31261678
http://dx.doi.org/10.3390/polym11071095
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