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Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms

Background and Objectives: Intracranial hemorrhage caused by the rupture of brain aneurysms occurs in almost 10 per 100,000 people whereas the incidence of such aneurysms is significantly higher, accounting for 4–9%. Linking certain factors to cerebral aneurysm rupture could help in explaining the s...

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Autores principales: Stojanović, Nebojša N., Kostić, Aleksandar, Mitić, Radisav, Berilažić, Luka, Radisavljević, Miša
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681035/
https://www.ncbi.nlm.nih.gov/pubmed/31277348
http://dx.doi.org/10.3390/medicina55070338
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author Stojanović, Nebojša N.
Kostić, Aleksandar
Mitić, Radisav
Berilažić, Luka
Radisavljević, Miša
author_facet Stojanović, Nebojša N.
Kostić, Aleksandar
Mitić, Radisav
Berilažić, Luka
Radisavljević, Miša
author_sort Stojanović, Nebojša N.
collection PubMed
description Background and Objectives: Intracranial hemorrhage caused by the rupture of brain aneurysms occurs in almost 10 per 100,000 people whereas the incidence of such aneurysms is significantly higher, accounting for 4–9%. Linking certain factors to cerebral aneurysm rupture could help in explaining the significantly lower incidence of their rupture compared to their presence. The aim of this study is to determine the association between the corresponding circle of Willis configurations and rupture of cerebral aneurysms. Materials and Methods: A group of 114 patients treated operatively for aruptured cerebral aneurysm and a group of 56 autopsied subjects were involved in the study. Four basic types of the circle of Willis configurations were formed—two symmetric types A and C, and two asymmetric types B and D. Results: A statistically significantly higher presence of asymmetry of the circle of Willis was determined in the group of surgically-treated subjects (p = 0.001),witha significant presence of asymmetric Type B in this group (p < 0.001). The changeson the A1 segment in the group of surgically-treated subjects showed a statistically significant presence compared to the group of autopsied subjects (p = 0.001). Analyzing the presence of symmetry of the circle of Willis between the two groups, that is, the total presence of symmetric types A and C, indicated their statistically significant presence in the group of autopsied patients (p < 0.001). Conclusions: Changes such as hypoplasia or aplasia of A1 and the resulting asymmetry of the circle of Willis directly affect the possibility of the rupture of cerebral aneurysms. Detection of the corresponding types of the circle of Willis after diagnostic examination can be the basis for the development of a protocol for monitoring such patients.
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spelling pubmed-66810352019-08-09 Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms Stojanović, Nebojša N. Kostić, Aleksandar Mitić, Radisav Berilažić, Luka Radisavljević, Miša Medicina (Kaunas) Article Background and Objectives: Intracranial hemorrhage caused by the rupture of brain aneurysms occurs in almost 10 per 100,000 people whereas the incidence of such aneurysms is significantly higher, accounting for 4–9%. Linking certain factors to cerebral aneurysm rupture could help in explaining the significantly lower incidence of their rupture compared to their presence. The aim of this study is to determine the association between the corresponding circle of Willis configurations and rupture of cerebral aneurysms. Materials and Methods: A group of 114 patients treated operatively for aruptured cerebral aneurysm and a group of 56 autopsied subjects were involved in the study. Four basic types of the circle of Willis configurations were formed—two symmetric types A and C, and two asymmetric types B and D. Results: A statistically significantly higher presence of asymmetry of the circle of Willis was determined in the group of surgically-treated subjects (p = 0.001),witha significant presence of asymmetric Type B in this group (p < 0.001). The changeson the A1 segment in the group of surgically-treated subjects showed a statistically significant presence compared to the group of autopsied subjects (p = 0.001). Analyzing the presence of symmetry of the circle of Willis between the two groups, that is, the total presence of symmetric types A and C, indicated their statistically significant presence in the group of autopsied patients (p < 0.001). Conclusions: Changes such as hypoplasia or aplasia of A1 and the resulting asymmetry of the circle of Willis directly affect the possibility of the rupture of cerebral aneurysms. Detection of the corresponding types of the circle of Willis after diagnostic examination can be the basis for the development of a protocol for monitoring such patients. MDPI 2019-07-03 /pmc/articles/PMC6681035/ /pubmed/31277348 http://dx.doi.org/10.3390/medicina55070338 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stojanović, Nebojša N.
Kostić, Aleksandar
Mitić, Radisav
Berilažić, Luka
Radisavljević, Miša
Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms
title Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms
title_full Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms
title_fullStr Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms
title_full_unstemmed Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms
title_short Association between Circle of Willis Configuration and Rupture of Cerebral Aneurysms
title_sort association between circle of willis configuration and rupture of cerebral aneurysms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681035/
https://www.ncbi.nlm.nih.gov/pubmed/31277348
http://dx.doi.org/10.3390/medicina55070338
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