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High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer

Background and objectives: Prostate cancer (PCa) is a common malignancy in males and has a relatively slower progression than other cancers. Our goal was to evaluate the clinical role of SPARC (secreted protein acidic and cysteine rich, osteonectin), cwcv, and kazal-like domains’ proteoglycan 1 (SPO...

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Autores principales: Chen, Mei-Ling, Ho, Cheng-Ju, Yeh, Chung-Min, Chen, Sung-Lang, Sung, Wen-Wei, Wang, Shao-Chuan, Chen, Chih-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681093/
https://www.ncbi.nlm.nih.gov/pubmed/31284511
http://dx.doi.org/10.3390/medicina55070343
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author Chen, Mei-Ling
Ho, Cheng-Ju
Yeh, Chung-Min
Chen, Sung-Lang
Sung, Wen-Wei
Wang, Shao-Chuan
Chen, Chih-Jung
author_facet Chen, Mei-Ling
Ho, Cheng-Ju
Yeh, Chung-Min
Chen, Sung-Lang
Sung, Wen-Wei
Wang, Shao-Chuan
Chen, Chih-Jung
author_sort Chen, Mei-Ling
collection PubMed
description Background and objectives: Prostate cancer (PCa) is a common malignancy in males and has a relatively slower progression than other cancers. Our goal was to evaluate the clinical role of SPARC (secreted protein acidic and cysteine rich, osteonectin), cwcv, and kazal-like domains’ proteoglycan 1 (SPOCK1) in PCa. Materials and Methods: SPOCK1 expression was studied through the immunohistochemical staining of specimens from 71 patients with PCa. The correlation between SPOCK1 expression and clinicopathological features was quantitatively analyzed. We used Kaplan–Meier analysis and Cox proportional hazard models to analyze the prognostic value. Results: Of 71 PCa patients, high SPOCK1 expression was more likely to be seen in those with an advanced stage (p = 0.018) of the disease and an advanced tumor (T) value (p = 0.014). Patients in Gleason grade groups 3 and 4 had significantly higher SPOCK1 expression (p = 0.044 and 0.003, respectively) compared to those of Gleason grade group 1. However, this trend was not observed in patients in Gleason grade group 5. For the survival analysis, although it was not statistically significant, patients with a high SPOCK1 expression had a shorter median overall survival (6.2 years) compared to those with low expression (7.8 years). Conclusions: High SPOCK1 expression may be related to advanced clinicopathological features and possibly a poor prognosis. Further analysis with a larger patient base would help clarify this issue.
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spelling pubmed-66810932019-08-09 High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer Chen, Mei-Ling Ho, Cheng-Ju Yeh, Chung-Min Chen, Sung-Lang Sung, Wen-Wei Wang, Shao-Chuan Chen, Chih-Jung Medicina (Kaunas) Article Background and objectives: Prostate cancer (PCa) is a common malignancy in males and has a relatively slower progression than other cancers. Our goal was to evaluate the clinical role of SPARC (secreted protein acidic and cysteine rich, osteonectin), cwcv, and kazal-like domains’ proteoglycan 1 (SPOCK1) in PCa. Materials and Methods: SPOCK1 expression was studied through the immunohistochemical staining of specimens from 71 patients with PCa. The correlation between SPOCK1 expression and clinicopathological features was quantitatively analyzed. We used Kaplan–Meier analysis and Cox proportional hazard models to analyze the prognostic value. Results: Of 71 PCa patients, high SPOCK1 expression was more likely to be seen in those with an advanced stage (p = 0.018) of the disease and an advanced tumor (T) value (p = 0.014). Patients in Gleason grade groups 3 and 4 had significantly higher SPOCK1 expression (p = 0.044 and 0.003, respectively) compared to those of Gleason grade group 1. However, this trend was not observed in patients in Gleason grade group 5. For the survival analysis, although it was not statistically significant, patients with a high SPOCK1 expression had a shorter median overall survival (6.2 years) compared to those with low expression (7.8 years). Conclusions: High SPOCK1 expression may be related to advanced clinicopathological features and possibly a poor prognosis. Further analysis with a larger patient base would help clarify this issue. MDPI 2019-07-05 /pmc/articles/PMC6681093/ /pubmed/31284511 http://dx.doi.org/10.3390/medicina55070343 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Mei-Ling
Ho, Cheng-Ju
Yeh, Chung-Min
Chen, Sung-Lang
Sung, Wen-Wei
Wang, Shao-Chuan
Chen, Chih-Jung
High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer
title High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer
title_full High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer
title_fullStr High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer
title_full_unstemmed High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer
title_short High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer
title_sort high spock1 expression is associated with advanced stage, t value, and gleason grade in prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681093/
https://www.ncbi.nlm.nih.gov/pubmed/31284511
http://dx.doi.org/10.3390/medicina55070343
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