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Hematologic Manifestations in Celiac Disease—A Practical Review

Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic on...

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Autores principales: Balaban, Daniel Vasile, Popp, Alina, Ionita Radu, Florentina, Jinga, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681208/
https://www.ncbi.nlm.nih.gov/pubmed/31311098
http://dx.doi.org/10.3390/medicina55070373
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author Balaban, Daniel Vasile
Popp, Alina
Ionita Radu, Florentina
Jinga, Mariana
author_facet Balaban, Daniel Vasile
Popp, Alina
Ionita Radu, Florentina
Jinga, Mariana
author_sort Balaban, Daniel Vasile
collection PubMed
description Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic ones are rather frequent and consist of anemia, thrombocytosis (thrombocytopenia also, but rare), thrombotic or hemorrhagic events, IgA deficiency, hyposplenism, and lymphoma. These hematologic alterations can be the sole manifestation of the disease and should prompt for CD testing in a suggestive clinical scenario. Recognition of these atypical, extraintestinal presentations, including hematologic ones, could represent a great opportunity to increase the diagnostic rate of CD, which is currently one of the most underdiagnosed chronic digestive disorders worldwide. In this review, we summarize recent evidence regarding the hematological manifestations of CD, with focus on practical recommendations for clinicians.
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spelling pubmed-66812082019-08-09 Hematologic Manifestations in Celiac Disease—A Practical Review Balaban, Daniel Vasile Popp, Alina Ionita Radu, Florentina Jinga, Mariana Medicina (Kaunas) Review Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic ones are rather frequent and consist of anemia, thrombocytosis (thrombocytopenia also, but rare), thrombotic or hemorrhagic events, IgA deficiency, hyposplenism, and lymphoma. These hematologic alterations can be the sole manifestation of the disease and should prompt for CD testing in a suggestive clinical scenario. Recognition of these atypical, extraintestinal presentations, including hematologic ones, could represent a great opportunity to increase the diagnostic rate of CD, which is currently one of the most underdiagnosed chronic digestive disorders worldwide. In this review, we summarize recent evidence regarding the hematological manifestations of CD, with focus on practical recommendations for clinicians. MDPI 2019-07-15 /pmc/articles/PMC6681208/ /pubmed/31311098 http://dx.doi.org/10.3390/medicina55070373 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Balaban, Daniel Vasile
Popp, Alina
Ionita Radu, Florentina
Jinga, Mariana
Hematologic Manifestations in Celiac Disease—A Practical Review
title Hematologic Manifestations in Celiac Disease—A Practical Review
title_full Hematologic Manifestations in Celiac Disease—A Practical Review
title_fullStr Hematologic Manifestations in Celiac Disease—A Practical Review
title_full_unstemmed Hematologic Manifestations in Celiac Disease—A Practical Review
title_short Hematologic Manifestations in Celiac Disease—A Practical Review
title_sort hematologic manifestations in celiac disease—a practical review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681208/
https://www.ncbi.nlm.nih.gov/pubmed/31311098
http://dx.doi.org/10.3390/medicina55070373
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