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Hematologic Manifestations in Celiac Disease—A Practical Review
Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic on...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681208/ https://www.ncbi.nlm.nih.gov/pubmed/31311098 http://dx.doi.org/10.3390/medicina55070373 |
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author | Balaban, Daniel Vasile Popp, Alina Ionita Radu, Florentina Jinga, Mariana |
author_facet | Balaban, Daniel Vasile Popp, Alina Ionita Radu, Florentina Jinga, Mariana |
author_sort | Balaban, Daniel Vasile |
collection | PubMed |
description | Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic ones are rather frequent and consist of anemia, thrombocytosis (thrombocytopenia also, but rare), thrombotic or hemorrhagic events, IgA deficiency, hyposplenism, and lymphoma. These hematologic alterations can be the sole manifestation of the disease and should prompt for CD testing in a suggestive clinical scenario. Recognition of these atypical, extraintestinal presentations, including hematologic ones, could represent a great opportunity to increase the diagnostic rate of CD, which is currently one of the most underdiagnosed chronic digestive disorders worldwide. In this review, we summarize recent evidence regarding the hematological manifestations of CD, with focus on practical recommendations for clinicians. |
format | Online Article Text |
id | pubmed-6681208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66812082019-08-09 Hematologic Manifestations in Celiac Disease—A Practical Review Balaban, Daniel Vasile Popp, Alina Ionita Radu, Florentina Jinga, Mariana Medicina (Kaunas) Review Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic ones are rather frequent and consist of anemia, thrombocytosis (thrombocytopenia also, but rare), thrombotic or hemorrhagic events, IgA deficiency, hyposplenism, and lymphoma. These hematologic alterations can be the sole manifestation of the disease and should prompt for CD testing in a suggestive clinical scenario. Recognition of these atypical, extraintestinal presentations, including hematologic ones, could represent a great opportunity to increase the diagnostic rate of CD, which is currently one of the most underdiagnosed chronic digestive disorders worldwide. In this review, we summarize recent evidence regarding the hematological manifestations of CD, with focus on practical recommendations for clinicians. MDPI 2019-07-15 /pmc/articles/PMC6681208/ /pubmed/31311098 http://dx.doi.org/10.3390/medicina55070373 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Balaban, Daniel Vasile Popp, Alina Ionita Radu, Florentina Jinga, Mariana Hematologic Manifestations in Celiac Disease—A Practical Review |
title | Hematologic Manifestations in Celiac Disease—A Practical Review |
title_full | Hematologic Manifestations in Celiac Disease—A Practical Review |
title_fullStr | Hematologic Manifestations in Celiac Disease—A Practical Review |
title_full_unstemmed | Hematologic Manifestations in Celiac Disease—A Practical Review |
title_short | Hematologic Manifestations in Celiac Disease—A Practical Review |
title_sort | hematologic manifestations in celiac disease—a practical review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681208/ https://www.ncbi.nlm.nih.gov/pubmed/31311098 http://dx.doi.org/10.3390/medicina55070373 |
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