Cargando…

Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)

Background and objectives: This study aimed to analyze and discern the differences in demographics and inpatient outcomes (length of stay (LOS), total charges, disease severity, and mortality) between depressed versus non-depressed sickle cell disease (SCD) patients. Materials and Methods: A retrosp...

Descripción completa

Detalles Bibliográficos
Autores principales: Onyeaka, Henry K., Queeneth, Uwandu, Rashid, Wahida, Ahmad, Naveed, Kuduva Rajan, Shanthini, Jaladi, Paul Rahul, Patel, Rikinkumar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681242/
https://www.ncbi.nlm.nih.gov/pubmed/31319584
http://dx.doi.org/10.3390/medicina55070385
_version_ 1783441686832087040
author Onyeaka, Henry K.
Queeneth, Uwandu
Rashid, Wahida
Ahmad, Naveed
Kuduva Rajan, Shanthini
Jaladi, Paul Rahul
Patel, Rikinkumar S.
author_facet Onyeaka, Henry K.
Queeneth, Uwandu
Rashid, Wahida
Ahmad, Naveed
Kuduva Rajan, Shanthini
Jaladi, Paul Rahul
Patel, Rikinkumar S.
author_sort Onyeaka, Henry K.
collection PubMed
description Background and objectives: This study aimed to analyze and discern the differences in demographics and inpatient outcomes (length of stay (LOS), total charges, disease severity, and mortality) between depressed versus non-depressed sickle cell disease (SCD) patients. Materials and Methods: A retrospective analysis was conducted using the Nationwide Inpatient Sample (2010–2014). We identified 73,225 SCD hospitalizations and comorbid depression (6317, 8.6%) as the primary and the other diagnosis, respectively, using International Classification of Diseases (ICD)-9 codes. We used linear and logistic regression model to evaluate the changes in inpatient outcomes. Results: Comorbid depression was more prevalent among middle-aged adults (11.5%), females (10.63%), and whites (12.43%). We did not find any association between income and comorbid depression among SCD patients. After adjusting for the demographic covariates, comorbid depression remained a significant risk factor for longer LOS (mean difference −1.16 days, 95% CI −1.30 to −1.03) and higher total charges (mean difference −USD5058, 95% CI −6261 to −3855) during hospitalization. SCD with comorbid depression was also significantly associated with a higher number of chronic conditions (mean difference −2.08, 95% CI −2.13 to −2.03) and 1.5 times (95% CI 1.39 to 1.63) higher odds of major severity of illness. Conclusion: Comorbid depression was significantly associated with longer LOS, more severity of illness, and higher hospital charges. Healthcare providers caring for adults with SCD should consider screening for and treating comorbid depression to improve the health-related quality of life.
format Online
Article
Text
id pubmed-6681242
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66812422019-08-09 Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS) Onyeaka, Henry K. Queeneth, Uwandu Rashid, Wahida Ahmad, Naveed Kuduva Rajan, Shanthini Jaladi, Paul Rahul Patel, Rikinkumar S. Medicina (Kaunas) Article Background and objectives: This study aimed to analyze and discern the differences in demographics and inpatient outcomes (length of stay (LOS), total charges, disease severity, and mortality) between depressed versus non-depressed sickle cell disease (SCD) patients. Materials and Methods: A retrospective analysis was conducted using the Nationwide Inpatient Sample (2010–2014). We identified 73,225 SCD hospitalizations and comorbid depression (6317, 8.6%) as the primary and the other diagnosis, respectively, using International Classification of Diseases (ICD)-9 codes. We used linear and logistic regression model to evaluate the changes in inpatient outcomes. Results: Comorbid depression was more prevalent among middle-aged adults (11.5%), females (10.63%), and whites (12.43%). We did not find any association between income and comorbid depression among SCD patients. After adjusting for the demographic covariates, comorbid depression remained a significant risk factor for longer LOS (mean difference −1.16 days, 95% CI −1.30 to −1.03) and higher total charges (mean difference −USD5058, 95% CI −6261 to −3855) during hospitalization. SCD with comorbid depression was also significantly associated with a higher number of chronic conditions (mean difference −2.08, 95% CI −2.13 to −2.03) and 1.5 times (95% CI 1.39 to 1.63) higher odds of major severity of illness. Conclusion: Comorbid depression was significantly associated with longer LOS, more severity of illness, and higher hospital charges. Healthcare providers caring for adults with SCD should consider screening for and treating comorbid depression to improve the health-related quality of life. MDPI 2019-07-17 /pmc/articles/PMC6681242/ /pubmed/31319584 http://dx.doi.org/10.3390/medicina55070385 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Onyeaka, Henry K.
Queeneth, Uwandu
Rashid, Wahida
Ahmad, Naveed
Kuduva Rajan, Shanthini
Jaladi, Paul Rahul
Patel, Rikinkumar S.
Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)
title Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)
title_full Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)
title_fullStr Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)
title_full_unstemmed Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)
title_short Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)
title_sort impact of depression in sickle cell disease hospitalization-related outcomes: an analysis of the national inpatient sample (nis)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681242/
https://www.ncbi.nlm.nih.gov/pubmed/31319584
http://dx.doi.org/10.3390/medicina55070385
work_keys_str_mv AT onyeakahenryk impactofdepressioninsicklecelldiseasehospitalizationrelatedoutcomesananalysisofthenationalinpatientsamplenis
AT queenethuwandu impactofdepressioninsicklecelldiseasehospitalizationrelatedoutcomesananalysisofthenationalinpatientsamplenis
AT rashidwahida impactofdepressioninsicklecelldiseasehospitalizationrelatedoutcomesananalysisofthenationalinpatientsamplenis
AT ahmadnaveed impactofdepressioninsicklecelldiseasehospitalizationrelatedoutcomesananalysisofthenationalinpatientsamplenis
AT kuduvarajanshanthini impactofdepressioninsicklecelldiseasehospitalizationrelatedoutcomesananalysisofthenationalinpatientsamplenis
AT jaladipaulrahul impactofdepressioninsicklecelldiseasehospitalizationrelatedoutcomesananalysisofthenationalinpatientsamplenis
AT patelrikinkumars impactofdepressioninsicklecelldiseasehospitalizationrelatedoutcomesananalysisofthenationalinpatientsamplenis