Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis

A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis...

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Autores principales: Tsurumaki, Hiroaki, Matsuyama, Toshiyuki, Ezawa, Kazuma, Koga, Yasuhiko, Yatomi, Masakiyo, Aoki-Saito, Haruka, Chikamatsu, Kazuaki, Hisada, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681373/
https://www.ncbi.nlm.nih.gov/pubmed/31277327
http://dx.doi.org/10.3390/medicina55070336
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author Tsurumaki, Hiroaki
Matsuyama, Toshiyuki
Ezawa, Kazuma
Koga, Yasuhiko
Yatomi, Masakiyo
Aoki-Saito, Haruka
Chikamatsu, Kazuaki
Hisada, Takeshi
author_facet Tsurumaki, Hiroaki
Matsuyama, Toshiyuki
Ezawa, Kazuma
Koga, Yasuhiko
Yatomi, Masakiyo
Aoki-Saito, Haruka
Chikamatsu, Kazuaki
Hisada, Takeshi
author_sort Tsurumaki, Hiroaki
collection PubMed
description A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis (ECRS) was made and benralizumab treatment was initiated; the blood eosinophil count subsequently decreased and lung function improved, thereby permitting OCS dose tapering. Surprisingly, benralizumab both reduced nasal polyps and ameliorated ECRS. Thus, benralizumab may be a useful drug for the rapid treatment of severe asthma with ECRS, especially in patients with hypereosinophilia.
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spelling pubmed-66813732019-08-09 Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis Tsurumaki, Hiroaki Matsuyama, Toshiyuki Ezawa, Kazuma Koga, Yasuhiko Yatomi, Masakiyo Aoki-Saito, Haruka Chikamatsu, Kazuaki Hisada, Takeshi Medicina (Kaunas) Case Report A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis (ECRS) was made and benralizumab treatment was initiated; the blood eosinophil count subsequently decreased and lung function improved, thereby permitting OCS dose tapering. Surprisingly, benralizumab both reduced nasal polyps and ameliorated ECRS. Thus, benralizumab may be a useful drug for the rapid treatment of severe asthma with ECRS, especially in patients with hypereosinophilia. MDPI 2019-07-03 /pmc/articles/PMC6681373/ /pubmed/31277327 http://dx.doi.org/10.3390/medicina55070336 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tsurumaki, Hiroaki
Matsuyama, Toshiyuki
Ezawa, Kazuma
Koga, Yasuhiko
Yatomi, Masakiyo
Aoki-Saito, Haruka
Chikamatsu, Kazuaki
Hisada, Takeshi
Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis
title Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis
title_full Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis
title_fullStr Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis
title_full_unstemmed Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis
title_short Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis
title_sort rapid effect of benralizumab for hypereosinophilia in a case of severe asthma with eosinophilic chronic rhinosinusitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681373/
https://www.ncbi.nlm.nih.gov/pubmed/31277327
http://dx.doi.org/10.3390/medicina55070336
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