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Eosinophilic esophagitis incidence in New Zealand: high but not increasing

BACKGROUND AND AIM: Eosinophilic esophagitis (EoE) is an immune-mediated inflammatory condition of the esophagus. Recent literature has shown an increasing incidence of the disease. However, no epidemiological data exist regarding New Zealand rates of EoE. The disease is associated with atopy, and N...

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Autores principales: Weerasekera, Kavindu, Sim, Dalice, Coughlan, Finbarr, Inns, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681430/
https://www.ncbi.nlm.nih.gov/pubmed/31534357
http://dx.doi.org/10.2147/CEG.S216126
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author Weerasekera, Kavindu
Sim, Dalice
Coughlan, Finbarr
Inns, Stephen
author_facet Weerasekera, Kavindu
Sim, Dalice
Coughlan, Finbarr
Inns, Stephen
author_sort Weerasekera, Kavindu
collection PubMed
description BACKGROUND AND AIM: Eosinophilic esophagitis (EoE) is an immune-mediated inflammatory condition of the esophagus. Recent literature has shown an increasing incidence of the disease. However, no epidemiological data exist regarding New Zealand rates of EoE. The disease is associated with atopy, and New Zealand’s high rate of atopic disease means the disease may be important in our population. We carried out a retrospective study to describe the incidence of EoE in the Wellington region of New Zealand, as well as key histological and clinical factors associated with the disease. METHOD: A search was made of laboratory and endoscopic databases in the Wellington region to identify all diagnosed cases in the five years between January 1, 2011, and December 31, 2015. Case notes were examined to determine the key demographic and clinical parameters in the cases. Incidence rates were calculated for each year, and the effects of age group and sex on the incidence rates were analyzed. RESULT: We found 152 cases of EoE in the Wellington region with an annual incidence of 6.95 per 100,000 person/years. We found no evidence of a significant difference in incidence rates by year in our study population. There was a significantly lower incidence rate in those aged <16 compared to those aged ≥16 (RR=0.26). Males had a higher incidence rate than females with an estimated rate ratio of 2.45 (p<0.05). CONCLUSION: Our results are in contrast to previous reports of increasing incidence rates and may reflect a leveling off of incidence. Further research is needed to determine whether the low incidence in our pediatric age group is due to ascertainment bias or due to a real difference in the epidemiology of EoE in NZ compared to other countries.
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spelling pubmed-66814302019-09-18 Eosinophilic esophagitis incidence in New Zealand: high but not increasing Weerasekera, Kavindu Sim, Dalice Coughlan, Finbarr Inns, Stephen Clin Exp Gastroenterol Original Research BACKGROUND AND AIM: Eosinophilic esophagitis (EoE) is an immune-mediated inflammatory condition of the esophagus. Recent literature has shown an increasing incidence of the disease. However, no epidemiological data exist regarding New Zealand rates of EoE. The disease is associated with atopy, and New Zealand’s high rate of atopic disease means the disease may be important in our population. We carried out a retrospective study to describe the incidence of EoE in the Wellington region of New Zealand, as well as key histological and clinical factors associated with the disease. METHOD: A search was made of laboratory and endoscopic databases in the Wellington region to identify all diagnosed cases in the five years between January 1, 2011, and December 31, 2015. Case notes were examined to determine the key demographic and clinical parameters in the cases. Incidence rates were calculated for each year, and the effects of age group and sex on the incidence rates were analyzed. RESULT: We found 152 cases of EoE in the Wellington region with an annual incidence of 6.95 per 100,000 person/years. We found no evidence of a significant difference in incidence rates by year in our study population. There was a significantly lower incidence rate in those aged <16 compared to those aged ≥16 (RR=0.26). Males had a higher incidence rate than females with an estimated rate ratio of 2.45 (p<0.05). CONCLUSION: Our results are in contrast to previous reports of increasing incidence rates and may reflect a leveling off of incidence. Further research is needed to determine whether the low incidence in our pediatric age group is due to ascertainment bias or due to a real difference in the epidemiology of EoE in NZ compared to other countries. Dove 2019-07-31 /pmc/articles/PMC6681430/ /pubmed/31534357 http://dx.doi.org/10.2147/CEG.S216126 Text en © 2019 Weerasekera et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Weerasekera, Kavindu
Sim, Dalice
Coughlan, Finbarr
Inns, Stephen
Eosinophilic esophagitis incidence in New Zealand: high but not increasing
title Eosinophilic esophagitis incidence in New Zealand: high but not increasing
title_full Eosinophilic esophagitis incidence in New Zealand: high but not increasing
title_fullStr Eosinophilic esophagitis incidence in New Zealand: high but not increasing
title_full_unstemmed Eosinophilic esophagitis incidence in New Zealand: high but not increasing
title_short Eosinophilic esophagitis incidence in New Zealand: high but not increasing
title_sort eosinophilic esophagitis incidence in new zealand: high but not increasing
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681430/
https://www.ncbi.nlm.nih.gov/pubmed/31534357
http://dx.doi.org/10.2147/CEG.S216126
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AT innsstephen eosinophilicesophagitisincidenceinnewzealandhighbutnotincreasing