The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck

Squamous cell carcinoma of the head and neck is a lethal disease with suboptimal survival outcomes and standard therapies with significant comorbidities. Whole exome sequencing data recently revealed an abundance of genetic and expression alterations in a family of enzymes known as protein methyltra...

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Autores principales: Saloura, Vassiliki, Vougiouklakis, Theodore, Sievers, Cem, Burkitt, Kyunghee, Nakamura, Yusuke, Hager, Gordon, van Waes, Carter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681457/
https://www.ncbi.nlm.nih.gov/pubmed/29884408
http://dx.doi.org/10.1016/j.oraloncology.2018.04.014
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author Saloura, Vassiliki
Vougiouklakis, Theodore
Sievers, Cem
Burkitt, Kyunghee
Nakamura, Yusuke
Hager, Gordon
van Waes, Carter
author_facet Saloura, Vassiliki
Vougiouklakis, Theodore
Sievers, Cem
Burkitt, Kyunghee
Nakamura, Yusuke
Hager, Gordon
van Waes, Carter
author_sort Saloura, Vassiliki
collection PubMed
description Squamous cell carcinoma of the head and neck is a lethal disease with suboptimal survival outcomes and standard therapies with significant comorbidities. Whole exome sequencing data recently revealed an abundance of genetic and expression alterations in a family of enzymes known as protein methyltransferases in a variety of cancer types, including squamous cell carcinoma of the head and neck. These enzymes are mostly known for their chromatin-modifying functions through methylation of various histone substrates, though evidence supports their function also through methylation of non-histone substrates. This review summarizes the current knowledge on the function of protein methyltransferases in squamous cell carcinoma of the head and neck and highlights their promising potential as the next generation of therapeutic targets in this disease.
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spelling pubmed-66814572019-08-05 The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck Saloura, Vassiliki Vougiouklakis, Theodore Sievers, Cem Burkitt, Kyunghee Nakamura, Yusuke Hager, Gordon van Waes, Carter Oral Oncol Article Squamous cell carcinoma of the head and neck is a lethal disease with suboptimal survival outcomes and standard therapies with significant comorbidities. Whole exome sequencing data recently revealed an abundance of genetic and expression alterations in a family of enzymes known as protein methyltransferases in a variety of cancer types, including squamous cell carcinoma of the head and neck. These enzymes are mostly known for their chromatin-modifying functions through methylation of various histone substrates, though evidence supports their function also through methylation of non-histone substrates. This review summarizes the current knowledge on the function of protein methyltransferases in squamous cell carcinoma of the head and neck and highlights their promising potential as the next generation of therapeutic targets in this disease. 2018-05-03 2018-06 /pmc/articles/PMC6681457/ /pubmed/29884408 http://dx.doi.org/10.1016/j.oraloncology.2018.04.014 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Saloura, Vassiliki
Vougiouklakis, Theodore
Sievers, Cem
Burkitt, Kyunghee
Nakamura, Yusuke
Hager, Gordon
van Waes, Carter
The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck
title The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck
title_full The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck
title_fullStr The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck
title_full_unstemmed The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck
title_short The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck
title_sort role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681457/
https://www.ncbi.nlm.nih.gov/pubmed/29884408
http://dx.doi.org/10.1016/j.oraloncology.2018.04.014
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