Cargando…

Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis

Clinical and experimental studies have shown that opisthorchii tend to evade tumour growth foci to colonize more distant areas of the liver. When modelling tumours with various carcinogens in the setting of superinvasive opisthorchiasis, the intensity of invasion is reduced both before the formation...

Descripción completa

Detalles Bibliográficos
Autores principales: Bychkov, Vitaly G., Kalyonova, Ludmila F., Khadieva, Elena D., Lazarev, Semen D., Lukmanov, Ilgiz R., Shidin, Vladimir A., Morozov, Evgeny N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681594/
https://www.ncbi.nlm.nih.gov/pubmed/31428553
http://dx.doi.org/10.1155/2019/8079368
_version_ 1783441754478870528
author Bychkov, Vitaly G.
Kalyonova, Ludmila F.
Khadieva, Elena D.
Lazarev, Semen D.
Lukmanov, Ilgiz R.
Shidin, Vladimir A.
Morozov, Evgeny N.
author_facet Bychkov, Vitaly G.
Kalyonova, Ludmila F.
Khadieva, Elena D.
Lazarev, Semen D.
Lukmanov, Ilgiz R.
Shidin, Vladimir A.
Morozov, Evgeny N.
author_sort Bychkov, Vitaly G.
collection PubMed
description Clinical and experimental studies have shown that opisthorchii tend to evade tumour growth foci to colonize more distant areas of the liver. When modelling tumours with various carcinogens in the setting of superinvasive opisthorchiasis, the intensity of invasion is reduced both before the formation of neoplasms (>120 days) and after the development of tumours of various histogeneses (liver, pancreas, and stomach) (>240 days). Egg production was observed to increase with the decrease in the number of parasites in the liver. The smallest changes in the infestation intensity indicators and egg production were observed in the experimental stomach tumours (p > 0.05). A partial hepatectomy in the setting of opisthorchiasis did not affect the number of parasites in the ecological niche (liver) or the production of eggs by the helminth. With the deterioration of the vegetation state, parasite clumps of opisthorchii increase egg production under the conditions of distress.
format Online
Article
Text
id pubmed-6681594
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-66815942019-08-19 Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis Bychkov, Vitaly G. Kalyonova, Ludmila F. Khadieva, Elena D. Lazarev, Semen D. Lukmanov, Ilgiz R. Shidin, Vladimir A. Morozov, Evgeny N. Anal Cell Pathol (Amst) Research Article Clinical and experimental studies have shown that opisthorchii tend to evade tumour growth foci to colonize more distant areas of the liver. When modelling tumours with various carcinogens in the setting of superinvasive opisthorchiasis, the intensity of invasion is reduced both before the formation of neoplasms (>120 days) and after the development of tumours of various histogeneses (liver, pancreas, and stomach) (>240 days). Egg production was observed to increase with the decrease in the number of parasites in the liver. The smallest changes in the infestation intensity indicators and egg production were observed in the experimental stomach tumours (p > 0.05). A partial hepatectomy in the setting of opisthorchiasis did not affect the number of parasites in the ecological niche (liver) or the production of eggs by the helminth. With the deterioration of the vegetation state, parasite clumps of opisthorchii increase egg production under the conditions of distress. Hindawi 2019-07-24 /pmc/articles/PMC6681594/ /pubmed/31428553 http://dx.doi.org/10.1155/2019/8079368 Text en Copyright © 2019 Vitaly G. Bychkov et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bychkov, Vitaly G.
Kalyonova, Ludmila F.
Khadieva, Elena D.
Lazarev, Semen D.
Lukmanov, Ilgiz R.
Shidin, Vladimir A.
Morozov, Evgeny N.
Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis
title Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis
title_full Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis
title_fullStr Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis
title_full_unstemmed Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis
title_short Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis
title_sort dynamics of the o. felineus infestation intensity and egg production in carcinogenesis and partial hepatectomy in the setting of superinvasive opisthorchiasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681594/
https://www.ncbi.nlm.nih.gov/pubmed/31428553
http://dx.doi.org/10.1155/2019/8079368
work_keys_str_mv AT bychkovvitalyg dynamicsoftheofelineusinfestationintensityandeggproductionincarcinogenesisandpartialhepatectomyinthesettingofsuperinvasiveopisthorchiasis
AT kalyonovaludmilaf dynamicsoftheofelineusinfestationintensityandeggproductionincarcinogenesisandpartialhepatectomyinthesettingofsuperinvasiveopisthorchiasis
AT khadievaelenad dynamicsoftheofelineusinfestationintensityandeggproductionincarcinogenesisandpartialhepatectomyinthesettingofsuperinvasiveopisthorchiasis
AT lazarevsemend dynamicsoftheofelineusinfestationintensityandeggproductionincarcinogenesisandpartialhepatectomyinthesettingofsuperinvasiveopisthorchiasis
AT lukmanovilgizr dynamicsoftheofelineusinfestationintensityandeggproductionincarcinogenesisandpartialhepatectomyinthesettingofsuperinvasiveopisthorchiasis
AT shidinvladimira dynamicsoftheofelineusinfestationintensityandeggproductionincarcinogenesisandpartialhepatectomyinthesettingofsuperinvasiveopisthorchiasis
AT morozovevgenyn dynamicsoftheofelineusinfestationintensityandeggproductionincarcinogenesisandpartialhepatectomyinthesettingofsuperinvasiveopisthorchiasis