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Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis

BACKGROUND: Previous studies exploring the association between toll-like receptor 4 (TLR4) polymorphisms and open angle glaucoma (OAG) presented inconsistent results. We aimed to investigate the association between TLR4 polymorphisms and OAG. METHODS: A systematic literature search was conducted in...

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Autores principales: Lin, Zhongjing, Huang, Shouyue, Sun, Jun, Xie, Bing, Zhong, Yisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681615/
https://www.ncbi.nlm.nih.gov/pubmed/31428642
http://dx.doi.org/10.1155/2019/6707650
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author Lin, Zhongjing
Huang, Shouyue
Sun, Jun
Xie, Bing
Zhong, Yisheng
author_facet Lin, Zhongjing
Huang, Shouyue
Sun, Jun
Xie, Bing
Zhong, Yisheng
author_sort Lin, Zhongjing
collection PubMed
description BACKGROUND: Previous studies exploring the association between toll-like receptor 4 (TLR4) polymorphisms and open angle glaucoma (OAG) presented inconsistent results. We aimed to investigate the association between TLR4 polymorphisms and OAG. METHODS: A systematic literature search was conducted in PubMed, EMBASE, ISI Web of Knowledge, and the Cochrane Library up to 31 December 2018. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated, followed by stratification analyses according to ethnicity and glaucoma subtype. RESULTS: TLR4 rs7037117 polymorphism had significant associations with increased risk of OAG in allelic model (OR=1.25; 95%CI: 1.09-1.44; P=0.002) and recessive model (OR=1.49; 95%CI: 1.08-2.04; P=0.01). With regard to rs10759930, rs12377632, and rs2149356, the results showed significant increased risks in all genetic models (all P<0.05), whereas, for rs1927914, rs11536889, and rs7045953, no significant associations were identified in any genetic model (all P>0.05). Furthermore, the association of rs1927911 with OAG risk was found to be significant in recessive model (OR=1.34; 95%CI: 1.06-1.71; P=0.02). As for rs4986790 and rs4986791, meta-analyses were not performed due to the limited number of studies and the ethnic differences. Subgroup analysis indicated that the above polymorphisms with significant differences might increase the susceptibility in POAG patients. As for the ethnicity, rs7037117, rs10759930, and rs1927911 might increase the risk in Asians, while rs12377632 and rs2149356 might increase the risk in Asians and Mexicans. CONCLUSION: The meta-analysis highlighted that certain mutations of some TLR4 polymorphisms might increase the susceptibility of OAG. However, TLR4 polymorphisms are still far from being candidate genetic biomarkers for OAG. Additional researches involving larger scale epidemiological studies are warranted to validate our results.
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spelling pubmed-66816152019-08-19 Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis Lin, Zhongjing Huang, Shouyue Sun, Jun Xie, Bing Zhong, Yisheng Biomed Res Int Review Article BACKGROUND: Previous studies exploring the association between toll-like receptor 4 (TLR4) polymorphisms and open angle glaucoma (OAG) presented inconsistent results. We aimed to investigate the association between TLR4 polymorphisms and OAG. METHODS: A systematic literature search was conducted in PubMed, EMBASE, ISI Web of Knowledge, and the Cochrane Library up to 31 December 2018. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated, followed by stratification analyses according to ethnicity and glaucoma subtype. RESULTS: TLR4 rs7037117 polymorphism had significant associations with increased risk of OAG in allelic model (OR=1.25; 95%CI: 1.09-1.44; P=0.002) and recessive model (OR=1.49; 95%CI: 1.08-2.04; P=0.01). With regard to rs10759930, rs12377632, and rs2149356, the results showed significant increased risks in all genetic models (all P<0.05), whereas, for rs1927914, rs11536889, and rs7045953, no significant associations were identified in any genetic model (all P>0.05). Furthermore, the association of rs1927911 with OAG risk was found to be significant in recessive model (OR=1.34; 95%CI: 1.06-1.71; P=0.02). As for rs4986790 and rs4986791, meta-analyses were not performed due to the limited number of studies and the ethnic differences. Subgroup analysis indicated that the above polymorphisms with significant differences might increase the susceptibility in POAG patients. As for the ethnicity, rs7037117, rs10759930, and rs1927911 might increase the risk in Asians, while rs12377632 and rs2149356 might increase the risk in Asians and Mexicans. CONCLUSION: The meta-analysis highlighted that certain mutations of some TLR4 polymorphisms might increase the susceptibility of OAG. However, TLR4 polymorphisms are still far from being candidate genetic biomarkers for OAG. Additional researches involving larger scale epidemiological studies are warranted to validate our results. Hindawi 2019-07-24 /pmc/articles/PMC6681615/ /pubmed/31428642 http://dx.doi.org/10.1155/2019/6707650 Text en Copyright © 2019 Zhongjing Lin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lin, Zhongjing
Huang, Shouyue
Sun, Jun
Xie, Bing
Zhong, Yisheng
Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis
title Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis
title_full Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis
title_fullStr Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis
title_full_unstemmed Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis
title_short Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis
title_sort associations between tlr4 polymorphisms and open angle glaucoma: a meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681615/
https://www.ncbi.nlm.nih.gov/pubmed/31428642
http://dx.doi.org/10.1155/2019/6707650
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