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Structural basis for adenylation and thioester bond formation in the ubiquitin E1

The ubiquitin (Ub) and Ub-like (Ubl) protein-conjugation cascade is initiated by E1 enzymes that catalyze Ub/Ubl activation through C-terminal adenylation, thioester bond formation with an E1 catalytic cysteine, and thioester bond transfer to Ub/Ubl E2 conjugating enzymes. Each of these reactions is...

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Detalles Bibliográficos
Autores principales:	Hann, Zachary S., Ji, Cheng, Olsen, Shaun K., Lu, Xuequan, Lux, Michaelyn C., Tan, Derek S., Lima, Christopher D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681703/ https://www.ncbi.nlm.nih.gov/pubmed/31235585 http://dx.doi.org/10.1073/pnas.1905488116

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