Computational and Experimental Druggability Assessment of Human DNA Glycosylases

[Image: see text] Due to a polar or even charged binding interface, DNA-binding proteins are considered extraordinarily difficult targets for development of small-molecule ligands and only a handful of proteins have been targeted successfully to date. Recently, however, it has been shown that develo...

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Detalles Bibliográficos
Autores principales: Michel, Maurice, Visnes, Torkild, Homan, Evert J., Seashore-Ludlow, Brinton, Hedenström, Mattias, Wiita, Elisée, Vallin, Karl, Paulin, Cynthia B. J., Zhang, Jiaxi, Wallner, Olov, Scobie, Martin, Schmidt, Andreas, Jenmalm-Jensen, Annika, Warpman Berglund, Ulrika, Helleday, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682003/
https://www.ncbi.nlm.nih.gov/pubmed/31460271
http://dx.doi.org/10.1021/acsomega.9b00162

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