Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides

[Image: see text] The physical and chemical interactions with vancomycin (VAN) were accessed between graphene oxide (GO) and crumpled graphene oxide (CGO) to present the possible loading and release mechanisms. The improved hydrophilicity and surface charge were found on CGO through water contact an...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Xing, Zhou, Ziyan, Han, Zhuo, Zeng, Yang, Chen, Xiaojie, Su, Jiacan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682005/
https://www.ncbi.nlm.nih.gov/pubmed/31460341
http://dx.doi.org/10.1021/acsomega.9b00873
_version_ 1783441809031036928
author He, Xing
Zhou, Ziyan
Han, Zhuo
Zeng, Yang
Chen, Xiaojie
Su, Jiacan
author_facet He, Xing
Zhou, Ziyan
Han, Zhuo
Zeng, Yang
Chen, Xiaojie
Su, Jiacan
author_sort He, Xing
collection PubMed
description [Image: see text] The physical and chemical interactions with vancomycin (VAN) were accessed between graphene oxide (GO) and crumpled graphene oxide (CGO) to present the possible loading and release mechanisms. The improved hydrophilicity and surface charge were found on CGO through water contact angle and ζ-potential measurements. Fourier transform infrared and X-ray photoelectron spectroscopies confirmed the attachment of VAN onto CGO or GO through π–π stacking and hydrogen bonding. Both CGO–VAN and GO–VAN drug complexes showed pH-controlled release property. The high VAN loading and delayed release in CGO–VAN system were mainly due to the crumpled morphology.
format Online
Article
Text
id pubmed-6682005
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-66820052019-08-27 Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides He, Xing Zhou, Ziyan Han, Zhuo Zeng, Yang Chen, Xiaojie Su, Jiacan ACS Omega [Image: see text] The physical and chemical interactions with vancomycin (VAN) were accessed between graphene oxide (GO) and crumpled graphene oxide (CGO) to present the possible loading and release mechanisms. The improved hydrophilicity and surface charge were found on CGO through water contact angle and ζ-potential measurements. Fourier transform infrared and X-ray photoelectron spectroscopies confirmed the attachment of VAN onto CGO or GO through π–π stacking and hydrogen bonding. Both CGO–VAN and GO–VAN drug complexes showed pH-controlled release property. The high VAN loading and delayed release in CGO–VAN system were mainly due to the crumpled morphology. American Chemical Society 2019-07-17 /pmc/articles/PMC6682005/ /pubmed/31460341 http://dx.doi.org/10.1021/acsomega.9b00873 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle He, Xing
Zhou, Ziyan
Han, Zhuo
Zeng, Yang
Chen, Xiaojie
Su, Jiacan
Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
title Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
title_full Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
title_fullStr Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
title_full_unstemmed Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
title_short Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
title_sort mechanism of controlled release of vancomycin from crumpled graphene oxides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682005/
https://www.ncbi.nlm.nih.gov/pubmed/31460341
http://dx.doi.org/10.1021/acsomega.9b00873
work_keys_str_mv AT hexing mechanismofcontrolledreleaseofvancomycinfromcrumpledgrapheneoxides
AT zhouziyan mechanismofcontrolledreleaseofvancomycinfromcrumpledgrapheneoxides
AT hanzhuo mechanismofcontrolledreleaseofvancomycinfromcrumpledgrapheneoxides
AT zengyang mechanismofcontrolledreleaseofvancomycinfromcrumpledgrapheneoxides
AT chenxiaojie mechanismofcontrolledreleaseofvancomycinfromcrumpledgrapheneoxides
AT sujiacan mechanismofcontrolledreleaseofvancomycinfromcrumpledgrapheneoxides

Ejemplares similares