Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles

[Image: see text] Iodine-catalyzed selective C-3 benzylation of indoles with benzylic alcohols is developed. The reaction proceeds with molecular iodine as the catalyst under ligand-, metal-, and base-free conditions and tolerates wide functionalities. The experimental observations account for the h...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhattacharjee, Prantika, Bora, Utpal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682061/
https://www.ncbi.nlm.nih.gov/pubmed/31460284
http://dx.doi.org/10.1021/acsomega.9b01481
_version_ 1783441822230511616
author Bhattacharjee, Prantika
Bora, Utpal
author_facet Bhattacharjee, Prantika
Bora, Utpal
author_sort Bhattacharjee, Prantika
collection PubMed
description [Image: see text] Iodine-catalyzed selective C-3 benzylation of indoles with benzylic alcohols is developed. The reaction proceeds with molecular iodine as the catalyst under ligand-, metal-, and base-free conditions and tolerates wide functionalities. The experimental observations account for the halogen-bond activation mechanistic pathway for the molecular iodine catalysis.
format Online
Article
Text
id pubmed-6682061
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-66820612019-08-27 Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles Bhattacharjee, Prantika Bora, Utpal ACS Omega [Image: see text] Iodine-catalyzed selective C-3 benzylation of indoles with benzylic alcohols is developed. The reaction proceeds with molecular iodine as the catalyst under ligand-, metal-, and base-free conditions and tolerates wide functionalities. The experimental observations account for the halogen-bond activation mechanistic pathway for the molecular iodine catalysis. American Chemical Society 2019-07-08 /pmc/articles/PMC6682061/ /pubmed/31460284 http://dx.doi.org/10.1021/acsomega.9b01481 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Bhattacharjee, Prantika
Bora, Utpal
Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles
title Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles
title_full Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles
title_fullStr Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles
title_full_unstemmed Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles
title_short Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles
title_sort molecular iodine-catalyzed selective c-3 benzylation of indoles with benzylic alcohols: a greener approach toward benzylated indoles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682061/
https://www.ncbi.nlm.nih.gov/pubmed/31460284
http://dx.doi.org/10.1021/acsomega.9b01481
work_keys_str_mv AT bhattacharjeeprantika moleculariodinecatalyzedselectivec3benzylationofindoleswithbenzylicalcoholsagreenerapproachtowardbenzylatedindoles
AT borautpal moleculariodinecatalyzedselectivec3benzylationofindoleswithbenzylicalcoholsagreenerapproachtowardbenzylatedindoles

Ejemplares similares