Catalyst- and Solvent-Free Coupling of 2-Methyl Quinazolinones and Isatins: An Environmentally Benign Access of Diastereoselective Schizocommunin Analogues

[Image: see text] An environmentally benign highly atom-economic protocol for the construction of the C–C bond has been developed under catalyst- and solvent-free conditions. This protocol involves the efficient coupling of 2-methyl quinazolinones with isatin for the highly diastereoselective access...

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Detalles Bibliográficos
Autores principales: Malviya, Bhanwar Kumar, Singh, Karandeep, Jaiswal, Pradeep K., Shukla, Monika, Verma, Ved Prakash, Vanangamudi, Murugesan, Jassal, Amanpreet Kaur, Punjabi, Pinki B., Sharma, Siddharth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682076/
https://www.ncbi.nlm.nih.gov/pubmed/31460329
http://dx.doi.org/10.1021/acsomega.9b01514
Descripción
Sumario:[Image: see text] An environmentally benign highly atom-economic protocol for the construction of the C–C bond has been developed under catalyst- and solvent-free conditions. This protocol involves the efficient coupling of 2-methyl quinazolinones with isatin for the highly diastereoselective access of schizocommunin derivatives in excellent yields (up to 97%). Furthermore, the preliminary cytotoxicity screening of selected schizocommunin analogues displayed promising anticancer activity against human cancer cell lines, and the cytotoxic potential of active compound 12ac was also validated by in silico molecular docking simulation studies.

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