Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution

[Image: see text] This work reports an operationally convenient ∼20 g scale synthesis of (S)-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic resolution of the corresponding racemate.

Detalles Bibliográficos
Autores principales: Mei, Haibo, Han, Jianlin, Takeda, Ryosuke, Sakamoto, Tsubasa, Miwa, Toshio, Minamitsuji, Yutaka, Moriwaki, Hiroki, Abe, Hidenori, Soloshonok, Vadim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682081/
https://www.ncbi.nlm.nih.gov/pubmed/31460294
http://dx.doi.org/10.1021/acsomega.9b01537
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author Mei, Haibo
Han, Jianlin
Takeda, Ryosuke
Sakamoto, Tsubasa
Miwa, Toshio
Minamitsuji, Yutaka
Moriwaki, Hiroki
Abe, Hidenori
Soloshonok, Vadim A.
author_facet Mei, Haibo
Han, Jianlin
Takeda, Ryosuke
Sakamoto, Tsubasa
Miwa, Toshio
Minamitsuji, Yutaka
Moriwaki, Hiroki
Abe, Hidenori
Soloshonok, Vadim A.
author_sort Mei, Haibo
collection PubMed
description [Image: see text] This work reports an operationally convenient ∼20 g scale synthesis of (S)-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic resolution of the corresponding racemate.
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spelling pubmed-66820812019-08-27 Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution Mei, Haibo Han, Jianlin Takeda, Ryosuke Sakamoto, Tsubasa Miwa, Toshio Minamitsuji, Yutaka Moriwaki, Hiroki Abe, Hidenori Soloshonok, Vadim A. ACS Omega [Image: see text] This work reports an operationally convenient ∼20 g scale synthesis of (S)-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic resolution of the corresponding racemate. American Chemical Society 2019-07-09 /pmc/articles/PMC6682081/ /pubmed/31460294 http://dx.doi.org/10.1021/acsomega.9b01537 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Mei, Haibo
Han, Jianlin
Takeda, Ryosuke
Sakamoto, Tsubasa
Miwa, Toshio
Minamitsuji, Yutaka
Moriwaki, Hiroki
Abe, Hidenori
Soloshonok, Vadim A.
Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution
title Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution
title_full Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution
title_fullStr Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution
title_full_unstemmed Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution
title_short Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution
title_sort practical method for preparation of (s)-2-amino-5,5,5-trifluoropentanoic acid via dynamic kinetic resolution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682081/
https://www.ncbi.nlm.nih.gov/pubmed/31460294
http://dx.doi.org/10.1021/acsomega.9b01537
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