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Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp(2))–C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones

[Image: see text] A novel, metal catalyst-free, and efficient method has been developed for the synthesis of (pyrazol-4-ylidene)pyridine derivatives. The process involves dehydrogenative coupling of 1-amino-2-imino-pyridines with 1-aryl-5-pyrazolone derivatives utilizing O(2) as the sole oxidant. Th...

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Detalles Bibliográficos
Autores principales: Ibrahim, Hamada Mohamed, Behbehani, Haider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682090/
https://www.ncbi.nlm.nih.gov/pubmed/31460276
http://dx.doi.org/10.1021/acsomega.9b01650
Descripción
Sumario:[Image: see text] A novel, metal catalyst-free, and efficient method has been developed for the synthesis of (pyrazol-4-ylidene)pyridine derivatives. The process involves dehydrogenative coupling of 1-amino-2-imino-pyridines with 1-aryl-5-pyrazolone derivatives utilizing O(2) as the sole oxidant. The new method benefits from a high atom economy, efficiency, and substrate scope, as well as the simplicity of reaction and product purification procedures.