Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp(2))–C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones

[Image: see text] A novel, metal catalyst-free, and efficient method has been developed for the synthesis of (pyrazol-4-ylidene)pyridine derivatives. The process involves dehydrogenative coupling of 1-amino-2-imino-pyridines with 1-aryl-5-pyrazolone derivatives utilizing O(2) as the sole oxidant. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Ibrahim, Hamada Mohamed, Behbehani, Haider
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682090/
https://www.ncbi.nlm.nih.gov/pubmed/31460276
http://dx.doi.org/10.1021/acsomega.9b01650
_version_ 1783441829055692800
author Ibrahim, Hamada Mohamed
Behbehani, Haider
author_facet Ibrahim, Hamada Mohamed
Behbehani, Haider
author_sort Ibrahim, Hamada Mohamed
collection PubMed
description [Image: see text] A novel, metal catalyst-free, and efficient method has been developed for the synthesis of (pyrazol-4-ylidene)pyridine derivatives. The process involves dehydrogenative coupling of 1-amino-2-imino-pyridines with 1-aryl-5-pyrazolone derivatives utilizing O(2) as the sole oxidant. The new method benefits from a high atom economy, efficiency, and substrate scope, as well as the simplicity of reaction and product purification procedures.
format Online
Article
Text
id pubmed-6682090
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-66820902019-08-27 Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp(2))–C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones Ibrahim, Hamada Mohamed Behbehani, Haider ACS Omega [Image: see text] A novel, metal catalyst-free, and efficient method has been developed for the synthesis of (pyrazol-4-ylidene)pyridine derivatives. The process involves dehydrogenative coupling of 1-amino-2-imino-pyridines with 1-aryl-5-pyrazolone derivatives utilizing O(2) as the sole oxidant. The new method benefits from a high atom economy, efficiency, and substrate scope, as well as the simplicity of reaction and product purification procedures. American Chemical Society 2019-07-05 /pmc/articles/PMC6682090/ /pubmed/31460276 http://dx.doi.org/10.1021/acsomega.9b01650 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Ibrahim, Hamada Mohamed
Behbehani, Haider
Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp(2))–C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones
title Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp(2))–C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones
title_full Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp(2))–C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones
title_fullStr Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp(2))–C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones
title_full_unstemmed Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp(2))–C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones
title_short Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp(2))–C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones
title_sort sustainable synthetic approach for (pyrazol-4-ylidene)pyridines by metal catalyst-free aerobic c(sp(2))–c(sp(3)) coupling reactions between 1-amino-2-imino-pyridines and 1-aryl-5-pyrazolones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682090/
https://www.ncbi.nlm.nih.gov/pubmed/31460276
http://dx.doi.org/10.1021/acsomega.9b01650
work_keys_str_mv AT ibrahimhamadamohamed sustainablesyntheticapproachforpyrazol4ylidenepyridinesbymetalcatalystfreeaerobiccsp2csp3couplingreactionsbetween1amino2iminopyridinesand1aryl5pyrazolones
AT behbehanihaider sustainablesyntheticapproachforpyrazol4ylidenepyridinesbymetalcatalystfreeaerobiccsp2csp3couplingreactionsbetween1amino2iminopyridinesand1aryl5pyrazolones

Ejemplares similares