Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I

[Image: see text] A label-free electrochemical immunosensor for cardiac troponin I was prepared by using a helical carbon nanotube-supported aldehyde-functionalized ionic liquid. Because of the good conductivity of ionic liquid and helical carbon nanotubes, high sensitivity of the immunosensor was o...

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Autores principales: Shen, Qihui, Liu, Man, Lü, Yang, Zhang, Dawei, Cheng, Zhenyu, Liu, Yan, Gao, Huajing, Jin, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682139/
https://www.ncbi.nlm.nih.gov/pubmed/31460299
http://dx.doi.org/10.1021/acsomega.9b01152
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author Shen, Qihui
Liu, Man
Lü, Yang
Zhang, Dawei
Cheng, Zhenyu
Liu, Yan
Gao, Huajing
Jin, Zhaohui
author_facet Shen, Qihui
Liu, Man
Lü, Yang
Zhang, Dawei
Cheng, Zhenyu
Liu, Yan
Gao, Huajing
Jin, Zhaohui
author_sort Shen, Qihui
collection PubMed
description [Image: see text] A label-free electrochemical immunosensor for cardiac troponin I was prepared by using a helical carbon nanotube-supported aldehyde-functionalized ionic liquid. Because of the good conductivity of ionic liquid and helical carbon nanotubes, high sensitivity of the immunosensor was obtained. Functionalized ionic liquid provided binding sites for antibody, which simplified the process of sensor construction. Cardiac troponin I was detected by this immunosensor with a linear range of 0.05–30 ng/mL and a detection limit of 0.03 ng/mL. The electrochemical immunosensor had satisfactory reproducibility, high sensitivity, and acceptable specificity.
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spelling pubmed-66821392019-08-27 Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I Shen, Qihui Liu, Man Lü, Yang Zhang, Dawei Cheng, Zhenyu Liu, Yan Gao, Huajing Jin, Zhaohui ACS Omega [Image: see text] A label-free electrochemical immunosensor for cardiac troponin I was prepared by using a helical carbon nanotube-supported aldehyde-functionalized ionic liquid. Because of the good conductivity of ionic liquid and helical carbon nanotubes, high sensitivity of the immunosensor was obtained. Functionalized ionic liquid provided binding sites for antibody, which simplified the process of sensor construction. Cardiac troponin I was detected by this immunosensor with a linear range of 0.05–30 ng/mL and a detection limit of 0.03 ng/mL. The electrochemical immunosensor had satisfactory reproducibility, high sensitivity, and acceptable specificity. American Chemical Society 2019-07-09 /pmc/articles/PMC6682139/ /pubmed/31460299 http://dx.doi.org/10.1021/acsomega.9b01152 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Shen, Qihui
Liu, Man
Lü, Yang
Zhang, Dawei
Cheng, Zhenyu
Liu, Yan
Gao, Huajing
Jin, Zhaohui
Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I
title Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I
title_full Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I
title_fullStr Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I
title_full_unstemmed Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I
title_short Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I
title_sort label-free electrochemical immunosensor based on a functionalized ionic liquid and helical carbon nanotubes for the determination of cardiac troponin i
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682139/
https://www.ncbi.nlm.nih.gov/pubmed/31460299
http://dx.doi.org/10.1021/acsomega.9b01152
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