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First Insight on Small Molecules as Cardiac Calsequestrin Stabilizers

[Image: see text] Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by mutations of cardiac calsequestrin (CASQ2) that impair its characteristic ability of Ca(2+)-induced polymerization–depolymerization. However, stabilizing the CASQ2 polymer by pharmacological agents to treat C...

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Detalles Bibliográficos
Autores principales:	Chakravarty, Harapriya, Bal, Chandralata, Yadav, Monika, Jena, Nivedita, Bal, Naresh C., Sharon, Ashoke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682146/ https://www.ncbi.nlm.nih.gov/pubmed/31460256 http://dx.doi.org/10.1021/acsomega.9b01113

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