Cargando…

Silencing of the MEKK2/MEKK3 Pathway Protects against Spinal Cord Injury via the Hedgehog Pathway and the JNK Pathway

Spinal cord injury (SCI) is a devastating medical condition, often accompanied by motor and sensory dysfunction. The Hedgehog (Hh) pathway has a protective role in pathological injury after SCI. However, the specific mechanism remains unclear. The present study aimed to confirm the effects of the mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Yan-Long, Wang, Yi-Fei, Zhu, Zhong-Sheng, Deng, Zheng-Wei, Chen, Jing, Zhang, Dong, Jiang, Qun-Hua, Zhao, Shi-Chang, Zhang, Ya-Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682310/ https://www.ncbi.nlm.nih.gov/pubmed/31382189 http://dx.doi.org/10.1016/j.omtn.2019.05.014

Ejemplares similares

Retraction Notice to: Silencing of the MEKK2/MEKK3 Pathway Protects against Spinal Cord Injury via the Hedgehog Pathway and the JNK Pathway
por: Kong, Yan-Long, et al.
Publicado: (2022)

MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function
por: Lu, Jinqiu, et al.
Publicado: (2018)

MEKK2 and MEKK3 orchestrate multiple signals to regulate Hippo pathway
por: Lu, Jinqiu, et al.
Publicado: (2021)

MarvelD3 couples tight junctions to the MEKK1–JNK pathway to regulate cell behavior and survival
por: Steed, Emily, et al.
Publicado: (2014)

SAK-HV Decreases the Self-Ubiquitination of MEKK1 to Promote Macrophage Proliferation via MAPK/ERK and JNK Pathways
por: Zhang, Chao, et al.
Publicado: (2017)

MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells
por: Zhang, Yonggang, et al.
Publicado: (2012)

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells
por: Ryabinina, Olga P, et al.
Publicado: (2006)

Overexpression of MEKK2 is associated with colorectal carcinogenesis
por: JIANG, LI, et al.
Publicado: (2013)

Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex
por: Fisher, Oriana S., et al.
Publicado: (2015)

Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR-206
por: Li, Qingman, et al.
Publicado: (2021)

Glutamate signalling via a MEKK1 kinase-dependent pathway induces changes in Arabidopsis root architecture
por: Forde, Brian G, et al.
Publicado: (2013)

A role for peroxiredoxins in H(2)O(2)- and MEKK-dependent activation of the p38 signaling pathway
por: Barata, Ana G., et al.
Publicado: (2019)

MEKK2 mediates aberrant ERK activation in neurofibromatosis type I
por: Bok, Seoyeon, et al.
Publicado: (2020)

MiR-132-3p Modulates MEKK3-Dependent NF-κB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages
por: Fang, Hua, et al.
Publicado: (2021)

Ste11p MEKK signals through HOG, mating, calcineurin and PKC pathways to regulate the FKS2 gene
por: Wang, Xiaoyan, et al.
Publicado: (2011)

A MEKK1 – JNK mitogen activated kinase (MAPK) cascade module is active in Echinococcus multilocularis stem cells
por: Stoll, Kristin, et al.
Publicado: (2021)

Apoptosis Induced by Cytoskeletal Disruption Requires Distinct Domains of MEKK1
por: Tricker, Erin, et al.
Publicado: (2011)

MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis
por: Xu, Dan, et al.
Publicado: (2018)

ALV-J inhibits autophagy through the GADD45β/MEKK4/P38MAPK signaling pathway and mediates apoptosis following autophagy
por: Liao, Zhihong, et al.
Publicado: (2020)

The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase
por: Cross, Janet V, et al.
Publicado: (2007)

Interaction with the Paxillin LD1 Motif Relieves MEKK2 Auto-inhibition
por: Kahle, Michael P., et al.
Publicado: (2015)

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines
por: Charlaftis, Nikolaos, et al.
Publicado: (2014)

MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation
por: Craig, Jane E., et al.
Publicado: (2020)

Prevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation
por: Enomoto, Atsushi, et al.
Publicado: (2019)

MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson’s disease
por: Yao, Longping, et al.
Publicado: (2018)

MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium
por: Zhang, Mei, et al.
Publicado: (2022)

MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
por: Lin, Chien-Huang, et al.
Publicado: (2018)

MicroRNA-520b Inhibits Growth of Hepatoma Cells by Targeting MEKK2 and Cyclin D1
por: Zhang, Weiying, et al.
Publicado: (2012)

Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model
por: Zhang, Ya-Dong, et al.
Publicado: (2017)

A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers
por: Filipčík, Pavel, et al.
Publicado: (2020)

MEKK1 Regulates Chemokine Expression in Mammary Fibroblasts: Implications for the Breast Tumor Microenvironment
por: Gentile, Saverio, et al.
Publicado: (2021)

Calcium Regulation of EGF-Induced ERK5 Activation: Role of Lad1-MEKK2 Interaction
por: Yao, Zhong, et al.
Publicado: (2010)

Intracellular Aggregation of Polypeptides with Expanded Polyglutamine Domain Is Stimulated by Stress-Activated Kinase Mekk1
por: Meriin, Anatoli B., et al.
Publicado: (2001)

HDAC4 promotes the growth and metastasis of gastric cancer via autophagic degradation of MEKK3
por: Zang, Wei-Jie, et al.
Publicado: (2022)

Functional characterization of MEKK3 in the intestinal immune response to bacterial challenges in grass carp (Ctenopharyngodon idella)
por: Qu, Fufa, et al.
Publicado: (2022)

MDMA targets miR-124/MEKK3 via MALAT1 to promote Parkinson’s disease progression
por: Geng, Xin, et al.
Publicado: (2023)

Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation
por: Yang, Xi, et al.
Publicado: (2023)

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling
por: Zhou, Zinan, et al.
Publicado: (2016)

E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2
por: Li, Hui, et al.
Publicado: (2022)

Young Sca-1(+) bone marrow stem cell-derived exosomes preserve visual function via the miR-150-5p/MEKK3/JNK/c-Jun pathway to reduce M1 microglial polarization
por: Wang, Yuan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2mmlcq0ld0b5f829s8geckt644