TEIPP peptides: exploration of unTAPped cancer antigens

The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers. Two recent papers describe which ‘hidden‘ antigens we might exploit to target these escaped cancer variants by CD8 T ce...

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Autores principales: Marijt, Koen A., Van Der Burg, Sjoerd H., van Hall, Thorbald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682355/
https://www.ncbi.nlm.nih.gov/pubmed/31413908
http://dx.doi.org/10.1080/2162402X.2019.1599639
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author Marijt, Koen A.
Van Der Burg, Sjoerd H.
van Hall, Thorbald
author_facet Marijt, Koen A.
Van Der Burg, Sjoerd H.
van Hall, Thorbald
author_sort Marijt, Koen A.
collection PubMed
description The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers. Two recent papers describe which ‘hidden‘ antigens we might exploit to target these escaped cancer variants by CD8 T cells. These unTAPped peptides are now ready for clinical testing.
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spelling pubmed-66823552019-08-14 TEIPP peptides: exploration of unTAPped cancer antigens Marijt, Koen A. Van Der Burg, Sjoerd H. van Hall, Thorbald Oncoimmunology Author’s View The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers. Two recent papers describe which ‘hidden‘ antigens we might exploit to target these escaped cancer variants by CD8 T cells. These unTAPped peptides are now ready for clinical testing. Taylor & Francis 2019-05-13 /pmc/articles/PMC6682355/ /pubmed/31413908 http://dx.doi.org/10.1080/2162402X.2019.1599639 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s View
Marijt, Koen A.
Van Der Burg, Sjoerd H.
van Hall, Thorbald
TEIPP peptides: exploration of unTAPped cancer antigens
title TEIPP peptides: exploration of unTAPped cancer antigens
title_full TEIPP peptides: exploration of unTAPped cancer antigens
title_fullStr TEIPP peptides: exploration of unTAPped cancer antigens
title_full_unstemmed TEIPP peptides: exploration of unTAPped cancer antigens
title_short TEIPP peptides: exploration of unTAPped cancer antigens
title_sort teipp peptides: exploration of untapped cancer antigens
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682355/
https://www.ncbi.nlm.nih.gov/pubmed/31413908
http://dx.doi.org/10.1080/2162402X.2019.1599639
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