Cargando…

Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

Active targeting and specific drug delivery to parenchymal liver cells is a promising strategy to treat various liver disorders. Here, we modified synthetic lipid-based nanoparticles with targeting peptides derived from the hepatitis B virus large envelope protein (HBVpreS) to specifically target th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Witzigmann, Dominik, Uhl, Philipp, Sieber, Sandro, Kaufman, Christina, Einfalt, Tomaz, Schöneweis, Katrin, Grossen, Philip, Buck, Jonas, Ni, Yi, Schenk, Susanne H, Hussner, Janine, Meyer zu Schwabedissen, Henriette E, Québatte, Gabriela, Mier, Walter, Urban, Stephan, Huwyler, Jörg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682401/ https://www.ncbi.nlm.nih.gov/pubmed/31333191 http://dx.doi.org/10.7554/eLife.42276

Ejemplares similares

Sodium(+)/taurocholate cotransporting polypeptide as target therapy for liver fibrosis
por: Salhab, Ahmad, et al.
Publicado: (2022)

Na(+)‐taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice
por: Slijepcevic, Davor, et al.
Publicado: (2018)

Clinical and histopathologic features of sodium taurocholate cotransporting polypeptide deficiency in pediatric patients
por: Dong, Chen, et al.
Publicado: (2019)

Hepatic Expression of the Na(+)-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation
por: Tremmel, Roman, et al.
Publicado: (2022)

Clinical and molecular study of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency
por: Deng, Mei, et al.
Publicado: (2016)

Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice
por: Roscam Abbing, Reinout L.P., et al.
Publicado: (2019)

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro
por: Saran, Chitra, et al.
Publicado: (2023)

Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+)-taurocholate cotransporting polypeptide knockout mice
por: Slijepcevic, Davor, et al.
Publicado: (2015)

Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics
por: Einfalt, Tomaž, et al.
Publicado: (2020)

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
por: Yan, Huan, et al.
Publicado: (2012)

Age‐dependent glycosylation of the sodium taurocholate cotransporter polypeptide: From fetal to adult human livers
por: Sargiacomo, Camillo, et al.
Publicado: (2018)

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na(+)‐Taurocholate Cotransporting Polypeptide
por: Robin, Marion J.D., et al.
Publicado: (2018)

Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes
por: Fukano, Kento, et al.
Publicado: (2019)

Monozygotic Twins Suffering From Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report
por: Tan, Hui-Jun, et al.
Publicado: (2018)

Structural Plasticity Is a Feature of Rheostat Positions in the Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP)
por: Ruggiero, Melissa J., et al.
Publicado: (2022)

Correction: Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
por: Yan, Huan, et al.
Publicado: (2014)

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
por: Burwitz, Benjamin J., et al.
Publicado: (2017)

A clinically relevant polymorphism in the Na(+)/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position
por: Ruggiero, Melissa J., et al.
Publicado: (2020)

Clinical features of sodium-taurocholate cotransporting polypeptide deficiency in pediatric patients: case series and literature review
por: Zou, Ting-Ting, et al.
Publicado: (2021)

Upregulation of HBV transcription by sodium taurocholate cotransporting polypeptide at the postentry step is inhibited by the entry inhibitor Myrcludex B
por: Zhao, Kaitao, et al.
Publicado: (2018)

The Lipid Raft Component Stomatin Interacts with the Na(+) Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake
por: Appelman, Monique D., et al.
Publicado: (2020)

Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide
por: Okuyama-Dobashi, Kaori, et al.
Publicado: (2015)

Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver
por: Nakabori, Tasuku, et al.
Publicado: (2016)

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection
por: Appelman, Monique D., et al.
Publicado: (2017)

Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
por: Miyakawa, Kei, et al.
Publicado: (2018)

Sodium Taurocholate Cotransporting Polypeptide (NTCP) Deficiency Hidden Behind Citrin Deficiency in Early Infancy: A Report of Three Cases
por: Lin, Hui, et al.
Publicado: (2019)

De novo mutation loci and clinical analysis in a child with sodium taurocholate cotransport polypeptide deficiency: A case report
por: Liu, Hui-Yan, et al.
Publicado: (2021)

Multitasking Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery
por: Zakrzewicz, Dariusz, et al.
Publicado: (2022)

Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status
por: Ezzikouri, Sayeh, et al.
Publicado: (2017)

Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide
por: Kaneko, Manabu, et al.
Publicado: (2018)

E-cadherin Plays a Role in Hepatitis B Virus Entry Through Affecting Glycosylated Sodium-Taurocholate Cotransporting Polypeptide Distribution
por: Hu, Qin, et al.
Publicado: (2020)

Establishment of a human cell line with a surface display system for screening and optimizing Na(+)-taurocholate cotransporting polypeptide-binding peptides
por: Wang, Pei-yun, et al.
Publicado: (2022)

Free Cholesterol Affects the Function and Localization of Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1)
por: Idowu, Jessica Y., et al.
Publicado: (2022)

Specific Binding and Endocytosis of Liposomes to HEK293T Cells via Myrisoylated Pre-S1 Peptide Bound to Sodium Taurocholate Cotransporting Polypeptide
por: Hinuma, Shuji, et al.
Publicado: (2022)

Primary Biliary Acids Inhibit Hepatitis D Virus (HDV) Entry into Human Hepatoma Cells Expressing the Sodium-Taurocholate Cotransporting Polypeptide (NTCP)
por: Veloso Alves Pereira, Isabel, et al.
Publicado: (2015)

Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry
por: Sargiacomo, Camillo, et al.
Publicado: (2017)

Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice
por: Slijepcevic, Davor, et al.
Publicado: (2017)

Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
por: Einfalt, T., et al.
Publicado: (2018)

Concentration of Na(+)-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus
por: Oswald, Andreas, et al.
Publicado: (2021)

Tyrosine 146 of the Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes
por: Zakrzewicz, Dariusz, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8tjb97b9dkis2s2oqgc57midtb