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Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice
Parkinson’s disease (PD) is a common neurodegenerative disease, featured by motor deficits and non-motor symptoms such as cognitive impairment, and malfunction of gamma-aminobutyric acid (GABA) mediated inhibitory transmission plays an important role in PD pathogenesis. The ginsenoside Rb1 molecule,...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682523/ https://www.ncbi.nlm.nih.gov/pubmed/31314744 http://dx.doi.org/10.18632/aging.102095 |
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author | Liu, Yan Zong, Xiaodan Huang, Jie Guan, Yanfei Li, Yuanquan Du, Ting Liu, Keyin Kang, Xinpan Dou, Chunyan Sun, Xiangdong Wu, Renhua Wen, Lei Zhang, Yunlong |
author_facet | Liu, Yan Zong, Xiaodan Huang, Jie Guan, Yanfei Li, Yuanquan Du, Ting Liu, Keyin Kang, Xinpan Dou, Chunyan Sun, Xiangdong Wu, Renhua Wen, Lei Zhang, Yunlong |
author_sort | Liu, Yan |
collection | PubMed |
description | Parkinson’s disease (PD) is a common neurodegenerative disease, featured by motor deficits and non-motor symptoms such as cognitive impairment, and malfunction of gamma-aminobutyric acid (GABA) mediated inhibitory transmission plays an important role in PD pathogenesis. The ginsenoside Rb1 molecule, a major constituent of the extract from the Ginseng root, has been demonstrated to ameliorate motor deficits and prevent dopaminergic neuron death in PD. However, whether Rb1 can regulate GABAergic transmission in PD-associated deficits and its underlying mechanisms are still unclear. In this study, we explored the effects of Rb1 on the GABAergic synaptic transmission in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. We demonstrated that Rb1 can bind with GABA(A)Rα1 and increase its expression in the SH-SY5Y cells and in the prefrontal cortex (PFC) of MPTP model in vitro and in vivo. Furthermore, Rb1 can promote prefrontal cortical GABA level and GABAergic transmission in MPTP-treated mice. We also revealed that Rb1 may suppress presynaptic GABA(B)R1 to enhance GABA release and GABA(A) receptor-mediated inhibitory transmission. In addition, Rb1 attenuated MPTP-induced dysfunctional gait dynamic and cognitive impairment, and this neuroprotective mechanism possibly involved regulating prefrontal cortical GABAergic transmission. Thus, Rb1 may serve as a potential drug candidate for the treatment of PD. |
format | Online Article Text |
id | pubmed-6682523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-66825232019-08-19 Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice Liu, Yan Zong, Xiaodan Huang, Jie Guan, Yanfei Li, Yuanquan Du, Ting Liu, Keyin Kang, Xinpan Dou, Chunyan Sun, Xiangdong Wu, Renhua Wen, Lei Zhang, Yunlong Aging (Albany NY) Research Paper Parkinson’s disease (PD) is a common neurodegenerative disease, featured by motor deficits and non-motor symptoms such as cognitive impairment, and malfunction of gamma-aminobutyric acid (GABA) mediated inhibitory transmission plays an important role in PD pathogenesis. The ginsenoside Rb1 molecule, a major constituent of the extract from the Ginseng root, has been demonstrated to ameliorate motor deficits and prevent dopaminergic neuron death in PD. However, whether Rb1 can regulate GABAergic transmission in PD-associated deficits and its underlying mechanisms are still unclear. In this study, we explored the effects of Rb1 on the GABAergic synaptic transmission in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. We demonstrated that Rb1 can bind with GABA(A)Rα1 and increase its expression in the SH-SY5Y cells and in the prefrontal cortex (PFC) of MPTP model in vitro and in vivo. Furthermore, Rb1 can promote prefrontal cortical GABA level and GABAergic transmission in MPTP-treated mice. We also revealed that Rb1 may suppress presynaptic GABA(B)R1 to enhance GABA release and GABA(A) receptor-mediated inhibitory transmission. In addition, Rb1 attenuated MPTP-induced dysfunctional gait dynamic and cognitive impairment, and this neuroprotective mechanism possibly involved regulating prefrontal cortical GABAergic transmission. Thus, Rb1 may serve as a potential drug candidate for the treatment of PD. Impact Journals 2019-07-17 /pmc/articles/PMC6682523/ /pubmed/31314744 http://dx.doi.org/10.18632/aging.102095 Text en Copyright © 2019 Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Liu, Yan Zong, Xiaodan Huang, Jie Guan, Yanfei Li, Yuanquan Du, Ting Liu, Keyin Kang, Xinpan Dou, Chunyan Sun, Xiangdong Wu, Renhua Wen, Lei Zhang, Yunlong Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice |
title | Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice |
title_full | Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice |
title_fullStr | Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice |
title_full_unstemmed | Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice |
title_short | Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice |
title_sort | ginsenoside rb1 regulates prefrontal cortical gabaergic transmission in mptp-treated mice |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682523/ https://www.ncbi.nlm.nih.gov/pubmed/31314744 http://dx.doi.org/10.18632/aging.102095 |
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