miR-548d-3p inhibits osteosarcoma by downregulating KRAS

MicroRNAs (miRNAs) are known to be associated with certain cancers, including osteosarcoma. We examined osteosarcoma tissues and cell lines, and found that most expressed lower levels of miR-548d-3p than adjacent tissues and normal cell lines. KRAS was identified as a potential target gene of miR-54...

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Detalles Bibliográficos
Autores principales: Chen, Jianhua, Yan, Chongnan, Yu, Honghao, Zhen, Shihan, Yuan, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682526/
https://www.ncbi.nlm.nih.gov/pubmed/31327761
http://dx.doi.org/10.18632/aging.102097
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author Chen, Jianhua
Yan, Chongnan
Yu, Honghao
Zhen, Shihan
Yuan, Quan
author_facet Chen, Jianhua
Yan, Chongnan
Yu, Honghao
Zhen, Shihan
Yuan, Quan
author_sort Chen, Jianhua
collection PubMed
description MicroRNAs (miRNAs) are known to be associated with certain cancers, including osteosarcoma. We examined osteosarcoma tissues and cell lines, and found that most expressed lower levels of miR-548d-3p than adjacent tissues and normal cell lines. KRAS was identified as a potential target gene of miR-548d-3p. In osteosarcoma cells, miR-548d-3p exerted tumor-suppressive effects by downregulating KRAS. Functional assays revealed that miR-548d-3p mimics dramatically reduced cell growth and migration in vitro. These results suggest that miR-548d-3p mimics could be applied for osteosarcoma treatment.
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spelling pubmed-66825262019-08-19 miR-548d-3p inhibits osteosarcoma by downregulating KRAS Chen, Jianhua Yan, Chongnan Yu, Honghao Zhen, Shihan Yuan, Quan Aging (Albany NY) Research Paper MicroRNAs (miRNAs) are known to be associated with certain cancers, including osteosarcoma. We examined osteosarcoma tissues and cell lines, and found that most expressed lower levels of miR-548d-3p than adjacent tissues and normal cell lines. KRAS was identified as a potential target gene of miR-548d-3p. In osteosarcoma cells, miR-548d-3p exerted tumor-suppressive effects by downregulating KRAS. Functional assays revealed that miR-548d-3p mimics dramatically reduced cell growth and migration in vitro. These results suggest that miR-548d-3p mimics could be applied for osteosarcoma treatment. Impact Journals 2019-07-21 /pmc/articles/PMC6682526/ /pubmed/31327761 http://dx.doi.org/10.18632/aging.102097 Text en Copyright © 2019 Chen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Chen, Jianhua
Yan, Chongnan
Yu, Honghao
Zhen, Shihan
Yuan, Quan
miR-548d-3p inhibits osteosarcoma by downregulating KRAS
title miR-548d-3p inhibits osteosarcoma by downregulating KRAS
title_full miR-548d-3p inhibits osteosarcoma by downregulating KRAS
title_fullStr miR-548d-3p inhibits osteosarcoma by downregulating KRAS
title_full_unstemmed miR-548d-3p inhibits osteosarcoma by downregulating KRAS
title_short miR-548d-3p inhibits osteosarcoma by downregulating KRAS
title_sort mir-548d-3p inhibits osteosarcoma by downregulating kras
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682526/
https://www.ncbi.nlm.nih.gov/pubmed/31327761
http://dx.doi.org/10.18632/aging.102097
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AT zhenshihan mir548d3pinhibitsosteosarcomabydownregulatingkras
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