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Autoimmunity Predisposition in Girls With Turner Syndrome
Background: Turner Syndrome is associated with an increased risk of autoimmune diseases, such as autoimmune thyroiditis, coeliac disease, type 1 diabetes mellitus, inflammatory bowel disease, alopecia areata, or vitiligo. The presence of isochromosome iXq and exposure to estradiol may contribute to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682631/ https://www.ncbi.nlm.nih.gov/pubmed/31417494 http://dx.doi.org/10.3389/fendo.2019.00511 |
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author | Wegiel, Malgorzata Antosz, Aleksandra Gieburowska, Joanna Szeliga, Kamila Hankus, Magdalena Grzybowska-Chlebowczyk, Urszula Wiecek, Sabina Malecka-Tendera, Ewa Gawlik, Aneta |
author_facet | Wegiel, Malgorzata Antosz, Aleksandra Gieburowska, Joanna Szeliga, Kamila Hankus, Magdalena Grzybowska-Chlebowczyk, Urszula Wiecek, Sabina Malecka-Tendera, Ewa Gawlik, Aneta |
author_sort | Wegiel, Malgorzata |
collection | PubMed |
description | Background: Turner Syndrome is associated with an increased risk of autoimmune diseases, such as autoimmune thyroiditis, coeliac disease, type 1 diabetes mellitus, inflammatory bowel disease, alopecia areata, or vitiligo. The presence of isochromosome iXq and exposure to estradiol may contribute to the development of the autoimmune process. The aim of this study was to determine the prevalence of autoimmune diseases in a group of TS patients and to assess the impact of karyotype and puberty on the development of autoimmune diseases. Patients and Methods: The analysis encompassed clinical and biochemical data of 134 patients treated between 2001 and 2018. All the patients were examined for autoimmune disease symptoms and tested for the presence of antithyroperoxidase (anti-TPO) and antithyreoglobulin (anti-TG) antibodies. In 73 of the patients, anti-transglutaminase (anti-tTG) antibodies were measured. Thyroid function was assessed by measuring TSH and fT4 levels. Results: The mean follow-up was 5.7 ± 3 years. An autoimmune disease was diagnosed in 46 (34.3%) patients: 39 (29.1%) had only one disorder, whilst 7 (5.2%) presented two disorders. The most common disorder, observed in 40 (29.9%) patients, was thyroid autoimmunity. Hashimoto disease was diagnosed in 20 (14.9%) patients. Of the 73 patients tested for coeliac disease, 4 (5.5%) had anti-tTG and 2 (2.7%) presented overt coeliac disease. Vitiligo was diagnosed in 3 (2.2%) patients, type 1 diabetes mellitus or psoriasis were diagnosed in 2 (1.5%) patients, whilst alopecia areata or lichen sclerosus were diagnosed in 1 (0.7%) patient. The impact of karyotype or estradiol exposure on developing autoimmune diseases were not statistically significant. Conclusions: Our study showed a higher incidence of autoimmune diseases in TS, which is in line with the literature; however, the impact of iXq, or spontaneous/inducted puberty was not confirmed. |
format | Online Article Text |
id | pubmed-6682631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66826312019-08-15 Autoimmunity Predisposition in Girls With Turner Syndrome Wegiel, Malgorzata Antosz, Aleksandra Gieburowska, Joanna Szeliga, Kamila Hankus, Magdalena Grzybowska-Chlebowczyk, Urszula Wiecek, Sabina Malecka-Tendera, Ewa Gawlik, Aneta Front Endocrinol (Lausanne) Endocrinology Background: Turner Syndrome is associated with an increased risk of autoimmune diseases, such as autoimmune thyroiditis, coeliac disease, type 1 diabetes mellitus, inflammatory bowel disease, alopecia areata, or vitiligo. The presence of isochromosome iXq and exposure to estradiol may contribute to the development of the autoimmune process. The aim of this study was to determine the prevalence of autoimmune diseases in a group of TS patients and to assess the impact of karyotype and puberty on the development of autoimmune diseases. Patients and Methods: The analysis encompassed clinical and biochemical data of 134 patients treated between 2001 and 2018. All the patients were examined for autoimmune disease symptoms and tested for the presence of antithyroperoxidase (anti-TPO) and antithyreoglobulin (anti-TG) antibodies. In 73 of the patients, anti-transglutaminase (anti-tTG) antibodies were measured. Thyroid function was assessed by measuring TSH and fT4 levels. Results: The mean follow-up was 5.7 ± 3 years. An autoimmune disease was diagnosed in 46 (34.3%) patients: 39 (29.1%) had only one disorder, whilst 7 (5.2%) presented two disorders. The most common disorder, observed in 40 (29.9%) patients, was thyroid autoimmunity. Hashimoto disease was diagnosed in 20 (14.9%) patients. Of the 73 patients tested for coeliac disease, 4 (5.5%) had anti-tTG and 2 (2.7%) presented overt coeliac disease. Vitiligo was diagnosed in 3 (2.2%) patients, type 1 diabetes mellitus or psoriasis were diagnosed in 2 (1.5%) patients, whilst alopecia areata or lichen sclerosus were diagnosed in 1 (0.7%) patient. The impact of karyotype or estradiol exposure on developing autoimmune diseases were not statistically significant. Conclusions: Our study showed a higher incidence of autoimmune diseases in TS, which is in line with the literature; however, the impact of iXq, or spontaneous/inducted puberty was not confirmed. Frontiers Media S.A. 2019-07-30 /pmc/articles/PMC6682631/ /pubmed/31417494 http://dx.doi.org/10.3389/fendo.2019.00511 Text en Copyright © 2019 Wegiel, Antosz, Gieburowska, Szeliga, Hankus, Grzybowska-Chlebowczyk, Wiecek, Malecka-Tendera and Gawlik. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Wegiel, Malgorzata Antosz, Aleksandra Gieburowska, Joanna Szeliga, Kamila Hankus, Magdalena Grzybowska-Chlebowczyk, Urszula Wiecek, Sabina Malecka-Tendera, Ewa Gawlik, Aneta Autoimmunity Predisposition in Girls With Turner Syndrome |
title | Autoimmunity Predisposition in Girls With Turner Syndrome |
title_full | Autoimmunity Predisposition in Girls With Turner Syndrome |
title_fullStr | Autoimmunity Predisposition in Girls With Turner Syndrome |
title_full_unstemmed | Autoimmunity Predisposition in Girls With Turner Syndrome |
title_short | Autoimmunity Predisposition in Girls With Turner Syndrome |
title_sort | autoimmunity predisposition in girls with turner syndrome |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682631/ https://www.ncbi.nlm.nih.gov/pubmed/31417494 http://dx.doi.org/10.3389/fendo.2019.00511 |
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