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Limitations and Off-Target Effects of Tryptophan-Related IDO Inhibitors in Cancer Treatment
Immunooncology is still a growing area in cancer therapy. Drugs within this therapeutic approach do not directly target/attack the tumor but interfere with immune checkpoints and target or reprogram key metabolic pathways critical for anti-cancer immune defense. Indolamine 2,3-dioxygenase 1 (IDO1) a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682646/ https://www.ncbi.nlm.nih.gov/pubmed/31417567 http://dx.doi.org/10.3389/fimmu.2019.01801 |