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Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation

Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”. Thus, HCMV-based vaccines are particularly interesting in order to stimulate a sustained and strong cellular immune response against cancer. Glioblas...

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Detalles Bibliográficos
Autores principales:	Abdelaziz, Mohammed O., Ossmann, Sophia, Kaufmann, Andreas M., Leitner, Judith, Steinberger, Peter, Willimsky, Gerald, Raftery, Martin J., Schönrich, Günther
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682651/ https://www.ncbi.nlm.nih.gov/pubmed/31417555 http://dx.doi.org/10.3389/fimmu.2019.01776

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