Cargando…

Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease

The pathological features of Alzheimer’s disease (AD) include senile plaques induced by amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within the brain. Recent observations have suggested t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yuan, Zhao, Yanfang, Zhang, Lei, Yu, Wanpeng, Wang, Yu, Chang, Wenguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682659/ https://www.ncbi.nlm.nih.gov/pubmed/31417361 http://dx.doi.org/10.3389/fncel.2019.00339

Ejemplares similares

β-Amyloid oligomers in aging and Alzheimer’s disease
por: Zahs, Kathleen R., et al.
Publicado: (2013)

Cellular Prion Protein Mediates Impairment of Synaptic Plasticity by Amyloid-β Oligomers
por: Laurén, Juha, et al.
Publicado: (2009)

Single-Molecule Imaging Reveals that Small Amyloid-β(1–42) Oligomers Interact with the Cellular Prion Protein (PrP(C))
por: Ganzinger, Kristina A, et al.
Publicado: (2014)

The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers
por: Stravalaci, Matteo, et al.
Publicado: (2016)

The Toxicity of Amyloid β Oligomers
por: Zhao, Li Na, et al.
Publicado: (2012)

The Role of Non-coding RNAs in Alzheimer’s Disease: From Regulated Mechanism to Therapeutic Targets and Diagnostic Biomarkers
por: Zhang, Yuan, et al.
Publicado: (2021)

Oligomer Formation by Amyloid-β42 in a Membrane-Mimicking Environment in Alzheimer’s Disease
por: Rosenberry, Terrone L., et al.
Publicado: (2022)

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers
por: Jarosz-Griffiths, Heledd H., et al.
Publicado: (2019)

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease
por: Ferreira, Sergio T., et al.
Publicado: (2015)

Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease
por: Hector, Audrey, et al.
Publicado: (2021)

Accumulation of cellular prion protein within β‐amyloid oligomer plaques in aged human brains
por: Takahashi, Reisuke H., et al.
Publicado: (2021)

Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer’s Disease
por: Mroczko, Barbara, et al.
Publicado: (2018)

The Toxicity and Polymorphism of β-Amyloid Oligomers
por: Huang, Ya-ru, et al.
Publicado: (2020)

The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer’s Disease
por: Viola, Kirsten L., et al.
Publicado: (2022)

ACU193: An Immunotherapeutic Poised to Test the Amyloid β Oligomer Hypothesis of Alzheimer’s Disease
por: Krafft, Grant A., et al.
Publicado: (2022)

Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function
por: Barucker, Christian, et al.
Publicado: (2015)

Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1
por: Rushworth, Jo V., et al.
Publicado: (2013)

Alzheimer Amyloid-β Oligomer Bound to Post-Synaptic Prion Protein Activates Fyn to Impair Neurons
por: Um, Ji Won, et al.
Publicado: (2012)

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
por: Limbocker, Ryan, et al.
Publicado: (2021)

Editorial: Beta-Amyloid oligomer specific treatments for Alzheimer's disease
por: Hillen, Heinz
Publicado: (2023)

Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils
por: Ahmed, Mahiuddin, et al.
Publicado: (2010)

Amyloid β-protein oligomers and Alzheimer’s disease
por: Hayden, Eric Y, et al.
Publicado: (2013)

Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer’s disease related oligomers
por: Lieblein, Tobias, et al.
Publicado: (2020)

Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease
por: Guerrero-Muñoz, Marcos J., et al.
Publicado: (2015)

Intra‐gastrointestinal amyloid‐β1–42 oligomers perturb enteric function and induce Alzheimer's disease pathology
por: Sun, Yayi, et al.
Publicado: (2020)

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β(1-42)
por: Bate, Clive, et al.
Publicado: (2004)

Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers
por: Novo, Mercedes, et al.
Publicado: (2018)

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
por: Sengupta, Urmi, et al.
Publicado: (2016)

Two mouse models of Alzheimer’s disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein
por: Purro, Silvia A., et al.
Publicado: (2023)

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity
por: Izzo, Nicholas J., et al.
Publicado: (2014)

Amyloid β-peptides 1–40 and 1–42 form oligomers with mixed β-sheets
por: Baldassarre, Maurizio, et al.
Publicado: (2017)

Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease
por: Lee, Ming-Che, et al.
Publicado: (2018)

Influence of denaturants on amyloid β42 aggregation kinetics
por: Weiffert, Tanja, et al.
Publicado: (2022)

Dynamic Changes in the Levels of Amyloid-β(42) Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer’s Disease
por: Zhang, Liding, et al.
Publicado: (2021)

S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation
por: Figueira, António J., et al.
Publicado: (2023)

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicity in Vivo
por: Fluharty, Brian R., et al.
Publicado: (2013)

Doxycycline for Alzheimer’s Disease: Fighting β-Amyloid Oligomers and Neuroinflammation
por: Balducci, Claudia, et al.
Publicado: (2019)

Ethanol Alleviates Amyloid-β-Induced Toxicity in an Alzheimer’s Disease Model of Caenorhabiditis elegans
por: Bai, Shuju, et al.
Publicado: (2021)

Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease
por: Watt, Nicole T., et al.
Publicado: (2014)

New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers
por: Ochiishi, Tomoyo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lj9qkjena3k61h89480po74us4