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Overexpression of PDE4A Acts as Checkpoint Inhibitor Against cAMP-Mediated Immunosuppression in vitro

Malignant cells acquire physiological mechanisms of immunosuppression to escape immune surveillance. Strategies to counteract this suppression could help to improve adoptive immunotherapy regimen. The intracellular second messenger cyclic AMP (cAMP) acts as a potent immunosuppressive signaling molec...

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Detalles Bibliográficos
Autores principales:	Schmetterer, Klaus G., Goldhahn, Katrin, Ziegler, Liesa S., Gerner, Marlene C., Schmidt, Ralf L. J., Themanns, Madeleine, Zebedin-Brandl, Eva, Trapin, Doris, Leitner, Judith, Pickl, Winfried F., Steinberger, Peter, Schwarzinger, Ilse, Marculescu, Rodrig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682678/ https://www.ncbi.nlm.nih.gov/pubmed/31417563 http://dx.doi.org/10.3389/fimmu.2019.01790

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