The serine protease HtrA1 cleaves misfolded transforming growth factor β–induced protein (TGFBIp) and induces amyloid formation

The serine protease high-temperature requirement protein A1 (HtrA1) is associated with protein-misfolding disorders such as Alzheimer's disease and transforming growth factor β–induced protein (TGFBIp)–linked corneal dystrophy. In this study, using several biochemical and biophysical approaches...

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Detalles Bibliográficos
Autores principales: Poulsen, Ebbe Toftgaard, Nielsen, Nadia Sukusu, Scavenius, Carsten, Mogensen, Emilie Hage, Risør, Michael W., Runager, Kasper, Lukassen, Marie V., Rasmussen, Casper B., Christiansen, Gunna, Richner, Mette, Vorum, Henrik, Enghild, Jan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682723/
https://www.ncbi.nlm.nih.gov/pubmed/31197037
http://dx.doi.org/10.1074/jbc.RA119.009050

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