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Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy

Background: Equine hepacivirus (EqHV) in equids represents the closest homologue to hepatitis C virus (HCV) infecting humans. A majority of HCV infected patients develop a chronic course of infection leading to liver fibrosis, cirrhosis and liver failure. However, in horses mostly transient mild sub...

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Autores principales: Tegtmeyer, Birthe, Echelmeyer, Julia, Pfankuche, Vanessa M., Puff, Christina, Todt, Daniel, Fischer, Nicole, Durham, Andy, Feige, Karsten, Baumgärtner, Wolfgang, Steinmann, Eike, Cavalleri, Jessika‐M. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682795/
https://www.ncbi.nlm.nih.gov/pubmed/31267690
http://dx.doi.org/10.1002/vms3.181
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author Tegtmeyer, Birthe
Echelmeyer, Julia
Pfankuche, Vanessa M.
Puff, Christina
Todt, Daniel
Fischer, Nicole
Durham, Andy
Feige, Karsten
Baumgärtner, Wolfgang
Steinmann, Eike
Cavalleri, Jessika‐M. V.
author_facet Tegtmeyer, Birthe
Echelmeyer, Julia
Pfankuche, Vanessa M.
Puff, Christina
Todt, Daniel
Fischer, Nicole
Durham, Andy
Feige, Karsten
Baumgärtner, Wolfgang
Steinmann, Eike
Cavalleri, Jessika‐M. V.
author_sort Tegtmeyer, Birthe
collection PubMed
description Background: Equine hepacivirus (EqHV) in equids represents the closest homologue to hepatitis C virus (HCV) infecting humans. A majority of HCV infected patients develop a chronic course of infection leading to liver fibrosis, cirrhosis and liver failure. However, in horses mostly transient mild subclinical infections are reported for EqHV to date. Objectives: EqHV can be involved in chronic liver diseases of horses. Methods: Biochemical parameters in serum samples were measured. Viral load was determined using qPCR. Next generation sequencing (NGS) of serum was performed. Liver tissue was stained with haematoxylin and eosin and analysed for viral RNA with fluorescent in situ‐hybridization. Results: The horse showed symptoms of severe hepatopathy and was chronically infected with EqHV. Viral RNA was detectable in the liver during disease. To rule out other infectious agents NGS was performed and showed the highest abundance for EqHV. The identified virus sequence was similar to other circulating equine hepaciviruses. Conclusions: EqHV can be associated with liver disease in horses. Whether it causes the disease or contributes in a multifactorial manner needs further investigation.
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spelling pubmed-66827952019-08-12 Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy Tegtmeyer, Birthe Echelmeyer, Julia Pfankuche, Vanessa M. Puff, Christina Todt, Daniel Fischer, Nicole Durham, Andy Feige, Karsten Baumgärtner, Wolfgang Steinmann, Eike Cavalleri, Jessika‐M. V. Vet Med Sci Case Report Background: Equine hepacivirus (EqHV) in equids represents the closest homologue to hepatitis C virus (HCV) infecting humans. A majority of HCV infected patients develop a chronic course of infection leading to liver fibrosis, cirrhosis and liver failure. However, in horses mostly transient mild subclinical infections are reported for EqHV to date. Objectives: EqHV can be involved in chronic liver diseases of horses. Methods: Biochemical parameters in serum samples were measured. Viral load was determined using qPCR. Next generation sequencing (NGS) of serum was performed. Liver tissue was stained with haematoxylin and eosin and analysed for viral RNA with fluorescent in situ‐hybridization. Results: The horse showed symptoms of severe hepatopathy and was chronically infected with EqHV. Viral RNA was detectable in the liver during disease. To rule out other infectious agents NGS was performed and showed the highest abundance for EqHV. The identified virus sequence was similar to other circulating equine hepaciviruses. Conclusions: EqHV can be associated with liver disease in horses. Whether it causes the disease or contributes in a multifactorial manner needs further investigation. John Wiley and Sons Inc. 2019-07-03 /pmc/articles/PMC6682795/ /pubmed/31267690 http://dx.doi.org/10.1002/vms3.181 Text en © 2019 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Report
Tegtmeyer, Birthe
Echelmeyer, Julia
Pfankuche, Vanessa M.
Puff, Christina
Todt, Daniel
Fischer, Nicole
Durham, Andy
Feige, Karsten
Baumgärtner, Wolfgang
Steinmann, Eike
Cavalleri, Jessika‐M. V.
Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy
title Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy
title_full Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy
title_fullStr Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy
title_full_unstemmed Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy
title_short Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy
title_sort chronic equine hepacivirus infection in an adult gelding with severe hepatopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682795/
https://www.ncbi.nlm.nih.gov/pubmed/31267690
http://dx.doi.org/10.1002/vms3.181
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