Cargando…

Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson’s Disease-Associated SH-SY5Y Cell Model

Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. In this study, we explored the neuroprotective effect and underlying molecular mechanism of vasicinone against paraquat-induced cellular apoptosis in SH-SY5Y cells. Vasicinone reduced the paraquat-induced loss of cell viab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ju, Da-Tong, Sivalingam, Kalaiselvi, Kuo, Wei-Wen, Ho, Tsung-Jung, Chang, Ruey-Lin, Chung, Li-Chin, Day, Cecilia Hsuan, Viswanadha, Vijaya Padma, Liao, Po-Hsiang, Huang, Chih-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682869/ https://www.ncbi.nlm.nih.gov/pubmed/31331066 http://dx.doi.org/10.3390/nu11071655

Ejemplares similares

Induction of Autophagy by Vasicinone Protects Neural Cells from Mitochondrial Dysfunction and Attenuates Paraquat-Mediated Parkinson’s Disease Associated α-Synuclein Levels
por: Huang, Chih-Yang, et al.
Publicado: (2020)

Differential Effects of Methyl-4-Phenylpyridinium Ion, Rotenone, and Paraquat on Differentiated SH-SY5Y Cells
por: Martins, João Barbosa, et al.
Publicado: (2013)

Protective Activity of Aspirin Eugenol Ester on Paraquat-Induced Cell Damage in SH-SY5Y Cells
por: Zhang, Zhen-Dong, et al.
Publicado: (2021)

Neferine, a bisbenzylisoquinoline alkaloid, offers protection against cobalt chloride-mediated hypoxia-induced oxidative stress in muscle cells
por: Baskaran, Rathinasamy, et al.
Publicado: (2015)

Bioactive Peptide VHVV Upregulates the Long-Term Memory-Related Biomarkers in Adult Spontaneously Hypertensive Rats
por: Ju, Da-Tong, et al.
Publicado: (2019)

IGF IIRα-triggered pathological manifestations in the heart aggravate renal inflammation in STZ-induced type-I diabetes rats
por: Lin, Henry Cherng-Han, et al.
Publicado: (2021)

Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells
por: Alural, Begum, et al.
Publicado: (2015)

Simultaneous determination of vasicine and vasicinone by High-performance liquid chromatography in roots of eight Sida species
por: Subramanya, M. D., et al.
Publicado: (2016)

β-catenin/LEF1/IGF-IIR Signaling Axis Galvanizes the Angiotensin-II- induced Cardiac Hypertrophy
por: Lai, Chin-Hu, et al.
Publicado: (2019)

An overview of targeted cancer therapy
por: Padma, Viswanadha Vijaya
Publicado: (2015)

Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells
por: Chornyy, Sergiy, et al.
Publicado: (2017)

Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein
por: Wu, Huan-Cheng, et al.
Publicado: (2018)

N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells
por: Cheng, Benxu, et al.
Publicado: (2016)

miR-186-5p Promotes Apoptosis by Targeting IGF-1 in SH-SY5Y OGD/R Model
por: Wang, Rui, et al.
Publicado: (2018)

Tanshinone IIA Inhibits β-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis
por: Chen, Ya-Fang, et al.
Publicado: (2017)

Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis
por: Wen, Su-Ying, et al.
Publicado: (2023)

Protective Effects of Jujubosides on 6-OHDA-Induced Neurotoxicity in SH-SY5Y and SK-N-SH Cells
por: Chen, Chao-Hsuan, et al.
Publicado: (2022)

Anti-Proliferative Activities of Vasicinone on Lung Carcinoma Cells Mediated via Activation of Both Mitochondria-Dependent and Independent Pathways
por: Dey, Tapan, et al.
Publicado: (2018)

Concurrent production and relative quantification of vasicinone from in vivo and in vitro plant parts of Malabar nut (Adhatoda vasica Nees)
por: Panigrahi, Jitendriya, et al.
Publicado: (2017)

Clusterin levels in undernourished SH-SY5Y cells
por: Rodríguez-Rivera, Carmen, et al.
Publicado: (2021)

Hesperidin Protects SH−SY5Y Neuronal Cells against High Glucose−Induced Apoptosis via Regulation of MAPK Signaling
por: Lim, Chaemoon, et al.
Publicado: (2022)

Osthole attenuated cytotoxicity induced by 6-OHDA in SH-SY5Y cells through inhibition of JAK/STAT and MAPK pathways
por: Barangi, Samira, et al.
Publicado: (2023)

Differential Expression of Multiple Disease-Related Protein Groups Induced by Valproic Acid in Human SH-SY5Y Neuroblastoma Cells
por: Hu, Tsung-Ming, et al.
Publicado: (2020)

Wound dressings – a review
por: Dhivya, Selvaraj, et al.
Publicado: (2015)

Quercetin Increases Mitochondrial Biogenesis and Reduces Free Radicals in Neuronal SH-SY5Y Cells
por: Ho, Chia-Ling, et al.
Publicado: (2022)

Endogenous Morphine in SH-SY5Y Cells and the Mouse Cerebellum
por: Muller, Arnaud, et al.
Publicado: (2008)

Cilostazol Suppresses Aβ-induced Neurotoxicity in SH-SY5Y Cells through Inhibition of Oxidative Stress and MAPK Signaling Pathway
por: Oguchi, Tatsunori, et al.
Publicado: (2017)

Palmitic Acid-Induced Neuron Cell Cycle G(2)/M Arrest and Endoplasmic Reticular Stress through Protein Palmitoylation in SH-SY5Y Human Neuroblastoma Cells
por: Hsiao, Yung-Hsuan, et al.
Publicado: (2014)

IGF-1 protects SH-SY5Y cells against MPP(+)-induced apoptosis via PI3K/PDK-1/Akt pathway
por: Kim, Chanyang, et al.
Publicado: (2018)

Neuroprotective effect of chondroitin sulfate on SH-SY5Y cells overexpressing wild-type or A53T mutant α-synuclein
por: Ju, Chuanxia, et al.
Publicado: (2017)

L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson’s Disease by Regulating Glutamine Metabolism
por: Zhang, Qingxi, et al.
Publicado: (2020)

CREB Negatively Regulates IGF2R Gene Expression and Downstream Pathways to Inhibit Hypoxia-Induced H9c2 Cardiomyoblast Cell Death
por: Chen, Wei-Kung, et al.
Publicado: (2015)

Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells
por: Yshii, Lidia M., et al.
Publicado: (2015)

Astaxanthin Inhibits Acetaldehyde-Induced Cytotoxicity in SH-SY5Y Cells by Modulating Akt/CREB and p38MAPK/ERK Signaling Pathways
por: Yan, Tingting, et al.
Publicado: (2016)

On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y
por: Pasdziernik, Markus, et al.
Publicado: (2009)

Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y
por: Yusuf, Mohammed, et al.
Publicado: (2012)

Protective effects of curcumin in APPswe transfected SH-SY5Y cells★
por: Yin, Wenke, et al.
Publicado: (2012)

The roles of valerenic acid on BDNF expression in the SH-SY5Y cell
por: Gonulalan, Ekrem-Murat, et al.
Publicado: (2018)

Nucleoredoxin Knockdown in SH-SY5Y Cells Promotes Cell Renewal
por: Valek, Lucie, et al.
Publicado: (2021)

Properties of differentiated SH-SY5Y grown on carbon-based materials
por: Yoon, Sae-Bom, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s4edd10n3b0u7vh95vg29rmh7s