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Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice

Sesame lignans, which are biologically active compounds present in sesame seeds and oil, are known to have neuroprotective effects in several models of brain dysfunction. However, the effects of sesame lignans on age-related brain dysfunction are not clear and were thus investigated in the present s...

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Autores principales: Shimoyoshi, Satomi, Takemoto, Daisuke, Ono, Yoshiko, Kitagawa, Yoshinori, Shibata, Hiroshi, Tomono, Susumu, Unno, Keiko, Wakabayashi, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682928/
https://www.ncbi.nlm.nih.gov/pubmed/31336975
http://dx.doi.org/10.3390/nu11071582
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author Shimoyoshi, Satomi
Takemoto, Daisuke
Ono, Yoshiko
Kitagawa, Yoshinori
Shibata, Hiroshi
Tomono, Susumu
Unno, Keiko
Wakabayashi, Keiji
author_facet Shimoyoshi, Satomi
Takemoto, Daisuke
Ono, Yoshiko
Kitagawa, Yoshinori
Shibata, Hiroshi
Tomono, Susumu
Unno, Keiko
Wakabayashi, Keiji
author_sort Shimoyoshi, Satomi
collection PubMed
description Sesame lignans, which are biologically active compounds present in sesame seeds and oil, are known to have neuroprotective effects in several models of brain dysfunction. However, the effects of sesame lignans on age-related brain dysfunction are not clear and were thus investigated in the present study using a senescence-accelerated mouse (SAMP10). Two-month-old male SAMP10 mice were administrated a basal diet with 0% or 0.05% sesame lignans for two months, or with 0%, 0.02%, or 0.05% sesame lignans for 10 months and subjected to step-through passive avoidance tasks and forced swim tests. Reactive carbonyl species (RCs) were evaluated as markers of oxidative stress using a recently developed comprehensive analytical method. Both learning time in passive avoidance tasks and immobile time in forced swim tests became longer with aging (p < 0.05). However, the administration of sesame lignans significantly ameliorated age-related effects in both tests (p < 0.05). Age-related increases in RCs such as 4-hydroxy-2-nonenal in the cerebral cortex and liver were reduced in mice fed sesame lignans. These results suggest that sesame lignans can prevent age-related brain dysfunction via anti-oxidative activity.
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spelling pubmed-66829282019-08-09 Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice Shimoyoshi, Satomi Takemoto, Daisuke Ono, Yoshiko Kitagawa, Yoshinori Shibata, Hiroshi Tomono, Susumu Unno, Keiko Wakabayashi, Keiji Nutrients Article Sesame lignans, which are biologically active compounds present in sesame seeds and oil, are known to have neuroprotective effects in several models of brain dysfunction. However, the effects of sesame lignans on age-related brain dysfunction are not clear and were thus investigated in the present study using a senescence-accelerated mouse (SAMP10). Two-month-old male SAMP10 mice were administrated a basal diet with 0% or 0.05% sesame lignans for two months, or with 0%, 0.02%, or 0.05% sesame lignans for 10 months and subjected to step-through passive avoidance tasks and forced swim tests. Reactive carbonyl species (RCs) were evaluated as markers of oxidative stress using a recently developed comprehensive analytical method. Both learning time in passive avoidance tasks and immobile time in forced swim tests became longer with aging (p < 0.05). However, the administration of sesame lignans significantly ameliorated age-related effects in both tests (p < 0.05). Age-related increases in RCs such as 4-hydroxy-2-nonenal in the cerebral cortex and liver were reduced in mice fed sesame lignans. These results suggest that sesame lignans can prevent age-related brain dysfunction via anti-oxidative activity. MDPI 2019-07-12 /pmc/articles/PMC6682928/ /pubmed/31336975 http://dx.doi.org/10.3390/nu11071582 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shimoyoshi, Satomi
Takemoto, Daisuke
Ono, Yoshiko
Kitagawa, Yoshinori
Shibata, Hiroshi
Tomono, Susumu
Unno, Keiko
Wakabayashi, Keiji
Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice
title Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice
title_full Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice
title_fullStr Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice
title_full_unstemmed Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice
title_short Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice
title_sort sesame lignans suppress age-related cognitive decline in senescence-accelerated mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682928/
https://www.ncbi.nlm.nih.gov/pubmed/31336975
http://dx.doi.org/10.3390/nu11071582
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