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Faster Gastric Emptying Is Unrelated to Feeding Success in Preterm Infants: Randomized Controlled Trial

Objectives: To evaluate the relationship between gastric emptying (GE) time and days to achievement of full enteral feeding (≥140 mL/kg/day) in preterm infants randomly assigned to receive one of two marketed study formulas for the first 14 feeding days: intact protein premature formula (IPF) or ext...

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Autores principales: Baldassarre, Maria Elisabetta, Di Mauro, Antonio, Montagna, Osvaldo, Fanelli, Margherita, Capozza, Manuela, Wampler, Jennifer L., Cooper, Timothy, Laforgia, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683060/
https://www.ncbi.nlm.nih.gov/pubmed/31330882
http://dx.doi.org/10.3390/nu11071670
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author Baldassarre, Maria Elisabetta
Di Mauro, Antonio
Montagna, Osvaldo
Fanelli, Margherita
Capozza, Manuela
Wampler, Jennifer L.
Cooper, Timothy
Laforgia, Nicola
author_facet Baldassarre, Maria Elisabetta
Di Mauro, Antonio
Montagna, Osvaldo
Fanelli, Margherita
Capozza, Manuela
Wampler, Jennifer L.
Cooper, Timothy
Laforgia, Nicola
author_sort Baldassarre, Maria Elisabetta
collection PubMed
description Objectives: To evaluate the relationship between gastric emptying (GE) time and days to achievement of full enteral feeding (≥140 mL/kg/day) in preterm infants randomly assigned to receive one of two marketed study formulas for the first 14 feeding days: intact protein premature formula (IPF) or extensively hydrolyzed protein (EHF) formula. Methods: In this triple-blind, controlled, prospective, clinical trial, we report GE time (time to half-emptying, t(1/2)) by real-time ultrasonography on Study Day 14, in preterm infants receiving IPF or EHF formula. The association between GE time and achievement of full enteral feeding was evaluated by Pearson correlation. Per-protocol populations for analysis included participants who (1) completed the study (overall) and (2) who received ≥ 75% study formula intake (mL/kg/day). Results: Median GE time at Day 14 was significantly faster for the EHF vs. IPF group overall and in participants who received ≥ 75% study formula intake (p ≤ 0.018). However, we demonstrated GE time had no correlation with the achievement of full enteral feeding (r = 0.08; p = 0.547). Conclusion: Feeding IP premature formula vs. EH formula was associated with shorter time to full enteral feeding. However, faster GE time did not predict feeding success and may not be a clinically relevant surrogate for assessing feeding tolerance.
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spelling pubmed-66830602019-08-09 Faster Gastric Emptying Is Unrelated to Feeding Success in Preterm Infants: Randomized Controlled Trial Baldassarre, Maria Elisabetta Di Mauro, Antonio Montagna, Osvaldo Fanelli, Margherita Capozza, Manuela Wampler, Jennifer L. Cooper, Timothy Laforgia, Nicola Nutrients Article Objectives: To evaluate the relationship between gastric emptying (GE) time and days to achievement of full enteral feeding (≥140 mL/kg/day) in preterm infants randomly assigned to receive one of two marketed study formulas for the first 14 feeding days: intact protein premature formula (IPF) or extensively hydrolyzed protein (EHF) formula. Methods: In this triple-blind, controlled, prospective, clinical trial, we report GE time (time to half-emptying, t(1/2)) by real-time ultrasonography on Study Day 14, in preterm infants receiving IPF or EHF formula. The association between GE time and achievement of full enteral feeding was evaluated by Pearson correlation. Per-protocol populations for analysis included participants who (1) completed the study (overall) and (2) who received ≥ 75% study formula intake (mL/kg/day). Results: Median GE time at Day 14 was significantly faster for the EHF vs. IPF group overall and in participants who received ≥ 75% study formula intake (p ≤ 0.018). However, we demonstrated GE time had no correlation with the achievement of full enteral feeding (r = 0.08; p = 0.547). Conclusion: Feeding IP premature formula vs. EH formula was associated with shorter time to full enteral feeding. However, faster GE time did not predict feeding success and may not be a clinically relevant surrogate for assessing feeding tolerance. MDPI 2019-07-21 /pmc/articles/PMC6683060/ /pubmed/31330882 http://dx.doi.org/10.3390/nu11071670 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baldassarre, Maria Elisabetta
Di Mauro, Antonio
Montagna, Osvaldo
Fanelli, Margherita
Capozza, Manuela
Wampler, Jennifer L.
Cooper, Timothy
Laforgia, Nicola
Faster Gastric Emptying Is Unrelated to Feeding Success in Preterm Infants: Randomized Controlled Trial
title Faster Gastric Emptying Is Unrelated to Feeding Success in Preterm Infants: Randomized Controlled Trial
title_full Faster Gastric Emptying Is Unrelated to Feeding Success in Preterm Infants: Randomized Controlled Trial
title_fullStr Faster Gastric Emptying Is Unrelated to Feeding Success in Preterm Infants: Randomized Controlled Trial
title_full_unstemmed Faster Gastric Emptying Is Unrelated to Feeding Success in Preterm Infants: Randomized Controlled Trial
title_short Faster Gastric Emptying Is Unrelated to Feeding Success in Preterm Infants: Randomized Controlled Trial
title_sort faster gastric emptying is unrelated to feeding success in preterm infants: randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683060/
https://www.ncbi.nlm.nih.gov/pubmed/31330882
http://dx.doi.org/10.3390/nu11071670
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