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Dairy Product Consumption and Prostate Cancer Risk in the United States
An ongoing controversy exists regarding the effect of dairy products on prostate cancer risk in observational studies. We prospectively investigated the associations between dairy product consumption and prostate cancer risk among men in the United States. After calculating pre-diagnostic intake of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683061/ https://www.ncbi.nlm.nih.gov/pubmed/31315238 http://dx.doi.org/10.3390/nu11071615 |
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author | Preble, Isabella Zhang, Zhenzhen Kopp, Ryan Garzotto, Mark Bobe, Gerd Shannon, Jackilen Takata, Yumie |
author_facet | Preble, Isabella Zhang, Zhenzhen Kopp, Ryan Garzotto, Mark Bobe, Gerd Shannon, Jackilen Takata, Yumie |
author_sort | Preble, Isabella |
collection | PubMed |
description | An ongoing controversy exists regarding the effect of dairy products on prostate cancer risk in observational studies. We prospectively investigated the associations between dairy product consumption and prostate cancer risk among men in the United States. After calculating pre-diagnostic intake of individual or subgroups of dairy products using a validated food frequency questionnaire, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for pathologically-verified cases of incident prostate cancer among men, overall, or stratified by severity. Among 49,472 men, 4134 were diagnosed with prostate cancer during an average follow-up period of 11.2 years. The median total dairy intake was 101 g/1000 kcal. Consumption of total, individual, or subgroups of dairy products was not statistically significantly associated with prostate cancer risk overall (HR = 1.05, 95% CI = 0.96–1.15 comparing the highest with lowest quartile) or stratified by severity, except for regular-fat dairy product intake with late-stage prostate cancer risk (HR = 1.37, 95% CI = 1.04–1.82 comparing the highest with lowest quartile) and 2%-fat milk intake with advanced prostate cancer risk (HR = 1.14, 95% CI = 1.02–1.28 comparing the higher than median intake with no intake group). Our findings do not support the previously reported harmful impact of dairy consumption on overall prostate cancer risk among men in the United States. |
format | Online Article Text |
id | pubmed-6683061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66830612019-08-09 Dairy Product Consumption and Prostate Cancer Risk in the United States Preble, Isabella Zhang, Zhenzhen Kopp, Ryan Garzotto, Mark Bobe, Gerd Shannon, Jackilen Takata, Yumie Nutrients Article An ongoing controversy exists regarding the effect of dairy products on prostate cancer risk in observational studies. We prospectively investigated the associations between dairy product consumption and prostate cancer risk among men in the United States. After calculating pre-diagnostic intake of individual or subgroups of dairy products using a validated food frequency questionnaire, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for pathologically-verified cases of incident prostate cancer among men, overall, or stratified by severity. Among 49,472 men, 4134 were diagnosed with prostate cancer during an average follow-up period of 11.2 years. The median total dairy intake was 101 g/1000 kcal. Consumption of total, individual, or subgroups of dairy products was not statistically significantly associated with prostate cancer risk overall (HR = 1.05, 95% CI = 0.96–1.15 comparing the highest with lowest quartile) or stratified by severity, except for regular-fat dairy product intake with late-stage prostate cancer risk (HR = 1.37, 95% CI = 1.04–1.82 comparing the highest with lowest quartile) and 2%-fat milk intake with advanced prostate cancer risk (HR = 1.14, 95% CI = 1.02–1.28 comparing the higher than median intake with no intake group). Our findings do not support the previously reported harmful impact of dairy consumption on overall prostate cancer risk among men in the United States. MDPI 2019-07-16 /pmc/articles/PMC6683061/ /pubmed/31315238 http://dx.doi.org/10.3390/nu11071615 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Preble, Isabella Zhang, Zhenzhen Kopp, Ryan Garzotto, Mark Bobe, Gerd Shannon, Jackilen Takata, Yumie Dairy Product Consumption and Prostate Cancer Risk in the United States |
title | Dairy Product Consumption and Prostate Cancer Risk in the United States |
title_full | Dairy Product Consumption and Prostate Cancer Risk in the United States |
title_fullStr | Dairy Product Consumption and Prostate Cancer Risk in the United States |
title_full_unstemmed | Dairy Product Consumption and Prostate Cancer Risk in the United States |
title_short | Dairy Product Consumption and Prostate Cancer Risk in the United States |
title_sort | dairy product consumption and prostate cancer risk in the united states |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683061/ https://www.ncbi.nlm.nih.gov/pubmed/31315238 http://dx.doi.org/10.3390/nu11071615 |
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