Enrichment technique to allow early detection and monitor emergence of KRAS mutation in response to treatment

Sensitivity of cell-free circulating tumour DNA (ctDNA) assays is often hampered by the limited quantity of intact mutant nucleotide fragments. To overcome the issue of substrate limitation in clinical applications, we developed an enrichment method utilizing pyrrole-imidazole (PI) polyamides and th...

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Detalles Bibliográficos
Autores principales: Kitagawa, Yoshiyasu, Okumura, Kazuhiro, Watanabe, Takayoshi, Tsukamoto, Kei, Kitano, Shiro, Nankinzan, Rino, Suzuki, Takuto, Hara, Taro, Soda, Hiroaki, Denda, Tadamichi, Yamaguchi, Taketo, Nagase, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683117/
https://www.ncbi.nlm.nih.gov/pubmed/31383871
http://dx.doi.org/10.1038/s41598-019-47700-9

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