A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients

A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA),a kind of active component from the most commonly used TCM li...

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Autores principales: Zhou, Neng, Zou, Caiyuan, Qin, Menglin, Li, Yi, Huang, Jiayi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683301/
https://www.ncbi.nlm.nih.gov/pubmed/31383927
http://dx.doi.org/10.1038/s41598-019-47880-4
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author Zhou, Neng
Zou, Caiyuan
Qin, Menglin
Li, Yi
Huang, Jiayi
author_facet Zhou, Neng
Zou, Caiyuan
Qin, Menglin
Li, Yi
Huang, Jiayi
author_sort Zhou, Neng
collection PubMed
description A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA),a kind of active component from the most commonly used TCM licorice. Our results revealed that all of the calibration curves displayed good linearity. Intra- and inter-day precision for GA ranged from 2.54 to 3.98% and from 4.95 to 7.08%, respectively. The recovery rates for GA were determined to be 96.3–106.4%. All the samples showed satisfactory precision and accuracy in various stability tests. Plasma pharmacokinetic parameters including area under the concentration-time curve (AUC), elimination half-life (t(1/2)), time to peak concentration(T(max)) and peak concentration C(max) were calculated. No significant difference was found as compared the groups administrating GA with and without other ingredients from TCM.
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spelling pubmed-66833012019-08-11 A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients Zhou, Neng Zou, Caiyuan Qin, Menglin Li, Yi Huang, Jiayi Sci Rep Article A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA),a kind of active component from the most commonly used TCM licorice. Our results revealed that all of the calibration curves displayed good linearity. Intra- and inter-day precision for GA ranged from 2.54 to 3.98% and from 4.95 to 7.08%, respectively. The recovery rates for GA were determined to be 96.3–106.4%. All the samples showed satisfactory precision and accuracy in various stability tests. Plasma pharmacokinetic parameters including area under the concentration-time curve (AUC), elimination half-life (t(1/2)), time to peak concentration(T(max)) and peak concentration C(max) were calculated. No significant difference was found as compared the groups administrating GA with and without other ingredients from TCM. Nature Publishing Group UK 2019-08-05 /pmc/articles/PMC6683301/ /pubmed/31383927 http://dx.doi.org/10.1038/s41598-019-47880-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhou, Neng
Zou, Caiyuan
Qin, Menglin
Li, Yi
Huang, Jiayi
A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients
title A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients
title_full A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients
title_fullStr A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients
title_full_unstemmed A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients
title_short A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients
title_sort simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683301/
https://www.ncbi.nlm.nih.gov/pubmed/31383927
http://dx.doi.org/10.1038/s41598-019-47880-4
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