Pre-clinical blocking of PD-L1 molecule, which expression is down regulated by NF-κB, JAK1/JAK2 and BTK inhibitors, induces regression of activated B-cell lymphoma

Escape from immune control must be important in the natural course of B-cell lymphomas, especially for those with activation of NF-κB. The pre-clinical LMP1/CD40-expressing transgenic mouse model is characterized by B-cell specific CD40 signaling responsible for NF-κB continuous activation with a sp...

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Detalles Bibliográficos
Autores principales: Vincent-Fabert, Christelle, Roland, Lilian, Zimber-Strobl, Ursula, Feuillard, Jean, Faumont, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683395/
https://www.ncbi.nlm.nih.gov/pubmed/31382969
http://dx.doi.org/10.1186/s12964-019-0391-x

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