CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches

BACKGROUND: CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L expressed on T cells results in the production of proinflammatory cytokines, induces T helper cell function...

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Detalles Bibliográficos
Autores principales: Argiriadi, Maria A., Benatuil, Lorenzo, Dubrovska, Ievgeniia, Egan, David A., Gao, Lei, Greischar, Amy, Hardman, Jennifer, Harlan, John, Iyer, Ramesh B., Judge, Russell A., Lake, Marc, Perron, Denise C., Sadhukhan, Ramkrishna, Sielaff, Bernhard, Sousa, Silvino, Wang, Rui, McRae, Bradford L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683420/
https://www.ncbi.nlm.nih.gov/pubmed/31382872
http://dx.doi.org/10.1186/s12860-019-0213-4

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