LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis

PURPOSE: MIR4435-2HG is an oncogenic lncRNA in gastric cancer and lung cancer. Our preliminary microarray data showed that MIR4435-2HG was downregulated in osteoarthritis plasma specimen, indicating the possible involvement of MIR4435-2HG in osteoarthritis. RESULTS: MIR4435-2HG was downregulated in...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Yu, Bao, Yucheng, Tang, Liang, Wang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683450/
https://www.ncbi.nlm.nih.gov/pubmed/31387631
http://dx.doi.org/10.1186/s13018-019-1278-7
_version_ 1783442094324449280
author Xiao, Yu
Bao, Yucheng
Tang, Liang
Wang, Li
author_facet Xiao, Yu
Bao, Yucheng
Tang, Liang
Wang, Li
author_sort Xiao, Yu
collection PubMed
description PURPOSE: MIR4435-2HG is an oncogenic lncRNA in gastric cancer and lung cancer. Our preliminary microarray data showed that MIR4435-2HG was downregulated in osteoarthritis plasma specimen, indicating the possible involvement of MIR4435-2HG in osteoarthritis. RESULTS: MIR4435-2HG was downregulated in plasma of osteoarthritis than in plasma of healthy controls. Reduced levels of MIR4435-2HG expression effectively distinguished osteoarthritis patients from the control group. Expression levels of MIR4435-2HG increased after treatment. Overexpression of MIR4435-2HG promoted, while MIR4435-2HG knockdown inhibited the proliferation of chondrocytes. In contrast, MIR4435-2HG overexpression inhibited, while MIR4435-2HG knockdown promoted the apoptosis of chondrocytes. CONCLUSION: MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis.
format Online
Article
Text
id pubmed-6683450
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-66834502019-08-09 LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis Xiao, Yu Bao, Yucheng Tang, Liang Wang, Li J Orthop Surg Res Research Article PURPOSE: MIR4435-2HG is an oncogenic lncRNA in gastric cancer and lung cancer. Our preliminary microarray data showed that MIR4435-2HG was downregulated in osteoarthritis plasma specimen, indicating the possible involvement of MIR4435-2HG in osteoarthritis. RESULTS: MIR4435-2HG was downregulated in plasma of osteoarthritis than in plasma of healthy controls. Reduced levels of MIR4435-2HG expression effectively distinguished osteoarthritis patients from the control group. Expression levels of MIR4435-2HG increased after treatment. Overexpression of MIR4435-2HG promoted, while MIR4435-2HG knockdown inhibited the proliferation of chondrocytes. In contrast, MIR4435-2HG overexpression inhibited, while MIR4435-2HG knockdown promoted the apoptosis of chondrocytes. CONCLUSION: MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis. BioMed Central 2019-08-06 /pmc/articles/PMC6683450/ /pubmed/31387631 http://dx.doi.org/10.1186/s13018-019-1278-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Xiao, Yu
Bao, Yucheng
Tang, Liang
Wang, Li
LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
title LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
title_full LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
title_fullStr LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
title_full_unstemmed LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
title_short LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
title_sort lncrna mir4435-2hg is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683450/
https://www.ncbi.nlm.nih.gov/pubmed/31387631
http://dx.doi.org/10.1186/s13018-019-1278-7
work_keys_str_mv AT xiaoyu lncrnamir44352hgisdownregulatedinosteoarthritisandregulateschondrocytecellproliferationandapoptosis
AT baoyucheng lncrnamir44352hgisdownregulatedinosteoarthritisandregulateschondrocytecellproliferationandapoptosis
AT tangliang lncrnamir44352hgisdownregulatedinosteoarthritisandregulateschondrocytecellproliferationandapoptosis
AT wangli lncrnamir44352hgisdownregulatedinosteoarthritisandregulateschondrocytecellproliferationandapoptosis

Ejemplares similares