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Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form

Paracetamol is an analgesic-antipyretic drug and Ibuprofen is a non-steroidal anti-inflammatory drug. They are co-formulated as tablets to improve analgesia, to simplify prescribing and to improve patient compliance. Three accurate, simple and sensitive spectrophotometric methods were developed for...

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Autores principales: El-Maraghy, Christine M., Lamie, Nesrine T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683492/
https://www.ncbi.nlm.nih.gov/pubmed/31406964
http://dx.doi.org/10.1186/s13065-019-0618-3
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author El-Maraghy, Christine M.
Lamie, Nesrine T.
author_facet El-Maraghy, Christine M.
Lamie, Nesrine T.
author_sort El-Maraghy, Christine M.
collection PubMed
description Paracetamol is an analgesic-antipyretic drug and Ibuprofen is a non-steroidal anti-inflammatory drug. They are co-formulated as tablets to improve analgesia, to simplify prescribing and to improve patient compliance. Three accurate, simple and sensitive spectrophotometric methods were developed for the simultaneous determination of Paracetamol and Ibuprofen in their co-formulated dosage form. The first method was the ratio difference, which was based on the measurement of the difference in absorbance between the two wavelengths (210.6 and 216.4 nm) for Ibuprofen and (236.0 and 248.0 nm) for Paracetamol. The second method was constant center method which depends on using the constant found in the ratio spectra. The third method was the mean centering of ratio spectra which measured the manipulated values at 240 nm and 237 nm for Ibuprofen and Paracetamol, respectively. Beer’s law was obeyed in the concentration range of 2–50 μg/mL for Ibuprofen and 2–20 μg/mL for Paracetamol. The recovery % of the accuracy of both methods ranged from 99.64 to 100.56%. Factors affecting the resolution of the spectra were studied and optimized. The three methods are validated according to ICH guidelines and could be applied for the pharmaceutical preparation.
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spelling pubmed-66834922019-08-12 Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form El-Maraghy, Christine M. Lamie, Nesrine T. BMC Chem Research Article Paracetamol is an analgesic-antipyretic drug and Ibuprofen is a non-steroidal anti-inflammatory drug. They are co-formulated as tablets to improve analgesia, to simplify prescribing and to improve patient compliance. Three accurate, simple and sensitive spectrophotometric methods were developed for the simultaneous determination of Paracetamol and Ibuprofen in their co-formulated dosage form. The first method was the ratio difference, which was based on the measurement of the difference in absorbance between the two wavelengths (210.6 and 216.4 nm) for Ibuprofen and (236.0 and 248.0 nm) for Paracetamol. The second method was constant center method which depends on using the constant found in the ratio spectra. The third method was the mean centering of ratio spectra which measured the manipulated values at 240 nm and 237 nm for Ibuprofen and Paracetamol, respectively. Beer’s law was obeyed in the concentration range of 2–50 μg/mL for Ibuprofen and 2–20 μg/mL for Paracetamol. The recovery % of the accuracy of both methods ranged from 99.64 to 100.56%. Factors affecting the resolution of the spectra were studied and optimized. The three methods are validated according to ICH guidelines and could be applied for the pharmaceutical preparation. Springer International Publishing 2019-08-06 /pmc/articles/PMC6683492/ /pubmed/31406964 http://dx.doi.org/10.1186/s13065-019-0618-3 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
El-Maraghy, Christine M.
Lamie, Nesrine T.
Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form
title Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form
title_full Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form
title_fullStr Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form
title_full_unstemmed Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form
title_short Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form
title_sort three smart spectrophotometric methods for resolution of severely overlapped binary mixture of ibuprofen and paracetamol in pharmaceutical dosage form
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683492/
https://www.ncbi.nlm.nih.gov/pubmed/31406964
http://dx.doi.org/10.1186/s13065-019-0618-3
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