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Genetic diversity and population structure of the Sapsaree, a native Korean dog breed

BACKGROUND: The Sapsaree is a breed of dog (Canis familiaris) native to Korea, which became perilously close to extinction in the mid-1980s. However, with systematic genetic conservation and restoration efforts, this breed was rescued from extinction and population sizes have been gradually increasi...

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Autores principales: Gajaweera, Chandima, Kang, Ji Min, Lee, Doo Ho, Lee, Soo Hyun, Kim, Yeong Kuk, Wijayananda, Hasini I., Kim, Jong Joo, Ha, Ji Hong, Choi, Bong Hwan, Lee, Seung Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683530/
https://www.ncbi.nlm.nih.gov/pubmed/31382890
http://dx.doi.org/10.1186/s12863-019-0757-5
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author Gajaweera, Chandima
Kang, Ji Min
Lee, Doo Ho
Lee, Soo Hyun
Kim, Yeong Kuk
Wijayananda, Hasini I.
Kim, Jong Joo
Ha, Ji Hong
Choi, Bong Hwan
Lee, Seung Hwan
author_facet Gajaweera, Chandima
Kang, Ji Min
Lee, Doo Ho
Lee, Soo Hyun
Kim, Yeong Kuk
Wijayananda, Hasini I.
Kim, Jong Joo
Ha, Ji Hong
Choi, Bong Hwan
Lee, Seung Hwan
author_sort Gajaweera, Chandima
collection PubMed
description BACKGROUND: The Sapsaree is a breed of dog (Canis familiaris) native to Korea, which became perilously close to extinction in the mid-1980s. However, with systematic genetic conservation and restoration efforts, this breed was rescued from extinction and population sizes have been gradually increasing over the past few decades. The aim of this study was to ascertain novel information about the genetic diversity, population structure, and demographic history of the Sapsaree breed using genome-wide single nucleotide polymorphism data. We characterized the genetic profile of the Sapsaree breed by comparison with seven foreign dog breeds with similar morphologies to estimate genetic differentiation within and among these breeds. RESULTS: The results suggest that Sapsarees have higher genetic variance compared with the other breeds analyzed. The majority of the Sapsarees in this study share a discrete genetic pattern, although some individuals were slightly different, possibly as a consequence of the recent restoration process. Concordant results from analyses of linkage disequilibrium, effective population size, genetic diversity, and population structural analyses illustrate a relationship among the Sapsaree and the Tibetan breeds Tibetan terrier and Lhasa Apso, and a small genetic introgression from European breeds. The effective population size of the Sapsaree has contracted dramatically over the past generations, and is currently insufficient to maintain long-term viability of the breed’s genetic diversity. CONCLUSIONS: This study provides novel insights regarding the genetic diversity and population structure of the native Korean dog breed Sapsaree. Our results suggest the importance of a strategic and systematic approach to ensure the genetic diversity and the authenticity of the Sapsaree breed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12863-019-0757-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-66835302019-08-09 Genetic diversity and population structure of the Sapsaree, a native Korean dog breed Gajaweera, Chandima Kang, Ji Min Lee, Doo Ho Lee, Soo Hyun Kim, Yeong Kuk Wijayananda, Hasini I. Kim, Jong Joo Ha, Ji Hong Choi, Bong Hwan Lee, Seung Hwan BMC Genet Research Article BACKGROUND: The Sapsaree is a breed of dog (Canis familiaris) native to Korea, which became perilously close to extinction in the mid-1980s. However, with systematic genetic conservation and restoration efforts, this breed was rescued from extinction and population sizes have been gradually increasing over the past few decades. The aim of this study was to ascertain novel information about the genetic diversity, population structure, and demographic history of the Sapsaree breed using genome-wide single nucleotide polymorphism data. We characterized the genetic profile of the Sapsaree breed by comparison with seven foreign dog breeds with similar morphologies to estimate genetic differentiation within and among these breeds. RESULTS: The results suggest that Sapsarees have higher genetic variance compared with the other breeds analyzed. The majority of the Sapsarees in this study share a discrete genetic pattern, although some individuals were slightly different, possibly as a consequence of the recent restoration process. Concordant results from analyses of linkage disequilibrium, effective population size, genetic diversity, and population structural analyses illustrate a relationship among the Sapsaree and the Tibetan breeds Tibetan terrier and Lhasa Apso, and a small genetic introgression from European breeds. The effective population size of the Sapsaree has contracted dramatically over the past generations, and is currently insufficient to maintain long-term viability of the breed’s genetic diversity. CONCLUSIONS: This study provides novel insights regarding the genetic diversity and population structure of the native Korean dog breed Sapsaree. Our results suggest the importance of a strategic and systematic approach to ensure the genetic diversity and the authenticity of the Sapsaree breed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12863-019-0757-5) contains supplementary material, which is available to authorized users. BioMed Central 2019-08-05 /pmc/articles/PMC6683530/ /pubmed/31382890 http://dx.doi.org/10.1186/s12863-019-0757-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Gajaweera, Chandima
Kang, Ji Min
Lee, Doo Ho
Lee, Soo Hyun
Kim, Yeong Kuk
Wijayananda, Hasini I.
Kim, Jong Joo
Ha, Ji Hong
Choi, Bong Hwan
Lee, Seung Hwan
Genetic diversity and population structure of the Sapsaree, a native Korean dog breed
title Genetic diversity and population structure of the Sapsaree, a native Korean dog breed
title_full Genetic diversity and population structure of the Sapsaree, a native Korean dog breed
title_fullStr Genetic diversity and population structure of the Sapsaree, a native Korean dog breed
title_full_unstemmed Genetic diversity and population structure of the Sapsaree, a native Korean dog breed
title_short Genetic diversity and population structure of the Sapsaree, a native Korean dog breed
title_sort genetic diversity and population structure of the sapsaree, a native korean dog breed
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683530/
https://www.ncbi.nlm.nih.gov/pubmed/31382890
http://dx.doi.org/10.1186/s12863-019-0757-5
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