A case report of a primary lymphoma of the tongue presenting as trigeminal neuralgia

BACKGROUND: Primary lymphoma of the oral cavity is a rare phenomenon. Herein we describe a unique presentation of lymphoma of the tongue which initially manifested as trigeminal neuralgia. CASE PRESENTATION: A 63-year-old female experienced a 10-month history of paresthesia and neuropathic pain involving the left tongue and mandibular area of her face. Investigations including imaging and biopsy revealed primary lymphoma of the tongue with extensive perineural spread. The patient underwent standard chemotherapy with complete radiological response, but minimal recovery of the affected neurological functions. CONCLUSION: This case highlights an unusual presentation of a rare disease leading to a delay in diagnosis and the importance of a complete workup for trigeminal neuropathy.