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Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity

BACKGROUND: Plasma-free amino acid profiles have been reported to correlate with obesity and glucose metabolism, and have been studied as potentially useful biomarkers of lifestyle-related diseases affecting metabolism in adulthood. However, knowledge of these relationships is lacking in children, d...

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Autores principales: Suzuki, Yosuke, Kido, Jun, Matsumoto, Shirou, Shimizu, Kie, Nakamura, Kimitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683574/
https://www.ncbi.nlm.nih.gov/pubmed/31387549
http://dx.doi.org/10.1186/s12887-019-1647-8
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author Suzuki, Yosuke
Kido, Jun
Matsumoto, Shirou
Shimizu, Kie
Nakamura, Kimitoshi
author_facet Suzuki, Yosuke
Kido, Jun
Matsumoto, Shirou
Shimizu, Kie
Nakamura, Kimitoshi
author_sort Suzuki, Yosuke
collection PubMed
description BACKGROUND: Plasma-free amino acid profiles have been reported to correlate with obesity and glucose metabolism, and have been studied as potentially useful biomarkers of lifestyle-related diseases affecting metabolism in adulthood. However, knowledge of these relationships is lacking in children, despite the growing public health problem posed by childhood obesity. The aim of this study was to assess whether plasma-free amino acid profiles can serve as useful biomarkers of lifestyle-related diseases in children with obesity. METHODS: This retrospective study used the medical records of 26 patients (15 male, 11 female) aged 9 or 10 years presenting with moderate to severe obesity and hyperlipidemia between April 2015 and March 2017. A degree of obesity of 30% or more was defined as moderate or severe. Amino acid levels were compared between obese children with and without impaired glucose tolerance using a t-test or Mann–Whitney U test. In addition, the influence of factors such as intima media thickness, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, amino acids, and homeostasis model assessment-insulin resistance (HOMA-IR) were analyzed pairwise using Pearson’s correlation or Spearman’s rank correlation. RESULTS: HOMA-IR was positively correlated with valine, leucine (Leu), isoleucine, phenylalanine, tryptophan, methionine, threonine, lysine, alanine, tyrosine, glutamate (Glu), proline, arginine, ornithine, total free amino acids (all P < 0.01), and aspartate (P = 0.010). Moreover, blood uric acid levels were positively correlated with Leu (P = 0.005) and Glu (P = 0.019), and negatively correlated with serine, glycine, and asparagine (P = 0.007, P = 0.003, and P = 0.013, respectively). CONCLUSIONS: Amino acid profile reflects impaired glucose tolerance and hyperuricemia at an early stage of obesity. It is therefore a useful marker to inform early intervention in children with obesity, as in adults. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12887-019-1647-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-66835742019-08-12 Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity Suzuki, Yosuke Kido, Jun Matsumoto, Shirou Shimizu, Kie Nakamura, Kimitoshi BMC Pediatr Research Article BACKGROUND: Plasma-free amino acid profiles have been reported to correlate with obesity and glucose metabolism, and have been studied as potentially useful biomarkers of lifestyle-related diseases affecting metabolism in adulthood. However, knowledge of these relationships is lacking in children, despite the growing public health problem posed by childhood obesity. The aim of this study was to assess whether plasma-free amino acid profiles can serve as useful biomarkers of lifestyle-related diseases in children with obesity. METHODS: This retrospective study used the medical records of 26 patients (15 male, 11 female) aged 9 or 10 years presenting with moderate to severe obesity and hyperlipidemia between April 2015 and March 2017. A degree of obesity of 30% or more was defined as moderate or severe. Amino acid levels were compared between obese children with and without impaired glucose tolerance using a t-test or Mann–Whitney U test. In addition, the influence of factors such as intima media thickness, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, amino acids, and homeostasis model assessment-insulin resistance (HOMA-IR) were analyzed pairwise using Pearson’s correlation or Spearman’s rank correlation. RESULTS: HOMA-IR was positively correlated with valine, leucine (Leu), isoleucine, phenylalanine, tryptophan, methionine, threonine, lysine, alanine, tyrosine, glutamate (Glu), proline, arginine, ornithine, total free amino acids (all P < 0.01), and aspartate (P = 0.010). Moreover, blood uric acid levels were positively correlated with Leu (P = 0.005) and Glu (P = 0.019), and negatively correlated with serine, glycine, and asparagine (P = 0.007, P = 0.003, and P = 0.013, respectively). CONCLUSIONS: Amino acid profile reflects impaired glucose tolerance and hyperuricemia at an early stage of obesity. It is therefore a useful marker to inform early intervention in children with obesity, as in adults. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12887-019-1647-8) contains supplementary material, which is available to authorized users. BioMed Central 2019-08-06 /pmc/articles/PMC6683574/ /pubmed/31387549 http://dx.doi.org/10.1186/s12887-019-1647-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Suzuki, Yosuke
Kido, Jun
Matsumoto, Shirou
Shimizu, Kie
Nakamura, Kimitoshi
Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity
title Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity
title_full Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity
title_fullStr Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity
title_full_unstemmed Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity
title_short Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity
title_sort associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683574/
https://www.ncbi.nlm.nih.gov/pubmed/31387549
http://dx.doi.org/10.1186/s12887-019-1647-8
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