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Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare Tumor of the Larynx
Lymphoepithelial carcinoma of the larynx is a rare tumor, as this histological entity is mostly diagnosed in nasopharynx. However, it may be present in other non-nasopharyngeal sites and it is extremely rare in the larynx. The authors present a case of a 59-year-old man who presented to the Otorhino...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683599/ https://www.ncbi.nlm.nih.gov/pubmed/31427858 http://dx.doi.org/10.1177/1179550619865551 |
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author | Monteiro, Francisco Baldaia, Helena Ribeiro, Leandro Sousa, Manuel Oliveira, Pedro Ferreira, Edite de Almeida, Mário Giesteira Condé, Artur |
author_facet | Monteiro, Francisco Baldaia, Helena Ribeiro, Leandro Sousa, Manuel Oliveira, Pedro Ferreira, Edite de Almeida, Mário Giesteira Condé, Artur |
author_sort | Monteiro, Francisco |
collection | PubMed |
description | Lymphoepithelial carcinoma of the larynx is a rare tumor, as this histological entity is mostly diagnosed in nasopharynx. However, it may be present in other non-nasopharyngeal sites and it is extremely rare in the larynx. The authors present a case of a 59-year-old man who presented to the Otorhinolaryngology–Head and Neck Surgery Department complaining of a long-standing dysphonia, odynophagia, and dysphagia. The clinical examination revealed a laryngeal tumor involving the right epiglottis, right aryepiglottic fold, and ipsilateral false vocal fold. It presented with ispilateral neck lymph node extension. Multiple biopsies of the laryngeal lesion were performed under local anesthesia and the histological examination showed a poorly differentiated squamous cell carcinoma. After discussing the case in a multidisciplinary tumor board, a total laryngectomy with a bilateral neck dissection was performed and the histological specimen showed a lymphoepithelial carcinoma. Although immunostaining with LMP-1 antibody was negative, in situ hybridization for Epstein-Barr virus was positive. He underwent adjuvant chemoradiation. He is now at 9-months follow-up period, with no evidence of disease. Lymphoepithelial carcinoma of the larynx is an extremely rare disease, with an aggressive pattern. Epstein-Barr virus–associated lymphoepithelial carcinoma has been exceptionally reported. A correct diagnosis and close collaboration with pathologist is crucial to achieve the best treatment strategy. We present this case to discuss the clinical and histology findings and the different therapeutic aspects of this uncommon histological subtype carcinoma. |
format | Online Article Text |
id | pubmed-6683599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-66835992019-08-19 Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare Tumor of the Larynx Monteiro, Francisco Baldaia, Helena Ribeiro, Leandro Sousa, Manuel Oliveira, Pedro Ferreira, Edite de Almeida, Mário Giesteira Condé, Artur Clin Med Insights Ear Nose Throat Commentary Lymphoepithelial carcinoma of the larynx is a rare tumor, as this histological entity is mostly diagnosed in nasopharynx. However, it may be present in other non-nasopharyngeal sites and it is extremely rare in the larynx. The authors present a case of a 59-year-old man who presented to the Otorhinolaryngology–Head and Neck Surgery Department complaining of a long-standing dysphonia, odynophagia, and dysphagia. The clinical examination revealed a laryngeal tumor involving the right epiglottis, right aryepiglottic fold, and ipsilateral false vocal fold. It presented with ispilateral neck lymph node extension. Multiple biopsies of the laryngeal lesion were performed under local anesthesia and the histological examination showed a poorly differentiated squamous cell carcinoma. After discussing the case in a multidisciplinary tumor board, a total laryngectomy with a bilateral neck dissection was performed and the histological specimen showed a lymphoepithelial carcinoma. Although immunostaining with LMP-1 antibody was negative, in situ hybridization for Epstein-Barr virus was positive. He underwent adjuvant chemoradiation. He is now at 9-months follow-up period, with no evidence of disease. Lymphoepithelial carcinoma of the larynx is an extremely rare disease, with an aggressive pattern. Epstein-Barr virus–associated lymphoepithelial carcinoma has been exceptionally reported. A correct diagnosis and close collaboration with pathologist is crucial to achieve the best treatment strategy. We present this case to discuss the clinical and histology findings and the different therapeutic aspects of this uncommon histological subtype carcinoma. SAGE Publications 2019-07-23 /pmc/articles/PMC6683599/ /pubmed/31427858 http://dx.doi.org/10.1177/1179550619865551 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Commentary Monteiro, Francisco Baldaia, Helena Ribeiro, Leandro Sousa, Manuel Oliveira, Pedro Ferreira, Edite de Almeida, Mário Giesteira Condé, Artur Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare Tumor of the Larynx |
title | Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare
Tumor of the Larynx |
title_full | Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare
Tumor of the Larynx |
title_fullStr | Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare
Tumor of the Larynx |
title_full_unstemmed | Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare
Tumor of the Larynx |
title_short | Epstein-Barr Virus–Associated With Lymphoepithelial Carcinoma: A Rare
Tumor of the Larynx |
title_sort | epstein-barr virus–associated with lymphoepithelial carcinoma: a rare
tumor of the larynx |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683599/ https://www.ncbi.nlm.nih.gov/pubmed/31427858 http://dx.doi.org/10.1177/1179550619865551 |
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