Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes

Phage display technology is a common approach for discovery of therapeutic antibodies. Drug candidates are typically isolated in two steps: First, a pool of antibodies is enriched through consecutive rounds of selection on a target antigen, and then individual clones are characterized in a screening...

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Detalles Bibliográficos
Autores principales: Ljungars, Anne, Svensson, Carolin, Carlsson, Anders, Birgersson, Elin, Tornberg, Ulla-Carin, Frendéus, Björn, Ohlin, Mats, Mattsson, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683657/
https://www.ncbi.nlm.nih.gov/pubmed/31417405
http://dx.doi.org/10.3389/fphar.2019.00847

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