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Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium
Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes. While it is known that these shapes are associated with spine function,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683673/ https://www.ncbi.nlm.nih.gov/pubmed/31324651 http://dx.doi.org/10.1085/jgp.201812261 |
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author | Bell, Miriam Bartol, Tom Sejnowski, Terrence Rangamani, Padmini |
author_facet | Bell, Miriam Bartol, Tom Sejnowski, Terrence Rangamani, Padmini |
author_sort | Bell, Miriam |
collection | PubMed |
description | Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes. While it is known that these shapes are associated with spine function, the specific nature of these shape–function relationships is not well understood. In this work, we systematically investigated the relationship between the shape and size of both the spine head and spine apparatus, a specialized endoplasmic reticulum compartment within the spine head, in modulating rapid calcium dynamics using mathematical modeling. We developed a spatial multicompartment reaction–diffusion model of calcium dynamics in three dimensions with various flux sources, including N-methyl-D-aspartate receptors (NMDARs), voltage-sensitive calcium channels (VSCCs), and different ion pumps on the plasma membrane. Using this model, we make several important predictions. First, the volume to surface area ratio of the spine regulates calcium dynamics. Second, membrane fluxes impact calcium dynamics temporally and spatially in a nonlinear fashion. Finally, the spine apparatus can act as a physical buffer for calcium by acting as a sink and rescaling the calcium concentration. These predictions set the stage for future experimental investigations of calcium dynamics in dendritic spines. |
format | Online Article Text |
id | pubmed-6683673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-66836732020-02-05 Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium Bell, Miriam Bartol, Tom Sejnowski, Terrence Rangamani, Padmini J Gen Physiol Research Articles Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes. While it is known that these shapes are associated with spine function, the specific nature of these shape–function relationships is not well understood. In this work, we systematically investigated the relationship between the shape and size of both the spine head and spine apparatus, a specialized endoplasmic reticulum compartment within the spine head, in modulating rapid calcium dynamics using mathematical modeling. We developed a spatial multicompartment reaction–diffusion model of calcium dynamics in three dimensions with various flux sources, including N-methyl-D-aspartate receptors (NMDARs), voltage-sensitive calcium channels (VSCCs), and different ion pumps on the plasma membrane. Using this model, we make several important predictions. First, the volume to surface area ratio of the spine regulates calcium dynamics. Second, membrane fluxes impact calcium dynamics temporally and spatially in a nonlinear fashion. Finally, the spine apparatus can act as a physical buffer for calcium by acting as a sink and rescaling the calcium concentration. These predictions set the stage for future experimental investigations of calcium dynamics in dendritic spines. Rockefeller University Press 2019-08-05 2019-07-19 /pmc/articles/PMC6683673/ /pubmed/31324651 http://dx.doi.org/10.1085/jgp.201812261 Text en © 2019 Bell et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Research Articles Bell, Miriam Bartol, Tom Sejnowski, Terrence Rangamani, Padmini Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium |
title | Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium |
title_full | Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium |
title_fullStr | Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium |
title_full_unstemmed | Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium |
title_short | Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium |
title_sort | dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683673/ https://www.ncbi.nlm.nih.gov/pubmed/31324651 http://dx.doi.org/10.1085/jgp.201812261 |
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