Spastin joins LDs and peroxisomes in the interorganelle contact ballet

Lipid droplets (LDs) store energy-rich fatty acids (FAs), but to harvest them, LDs donate FAs to peroxisomes for oxidation. In this issue, Chang et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902061) identify M1 Spastin as an LD–peroxisome tether that interacts with ESCRT-III components...

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Detalles Bibliográficos
Autor principal: Henne, W. Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683730/
https://www.ncbi.nlm.nih.gov/pubmed/31278079
http://dx.doi.org/10.1083/jcb.201906025
Descripción
Sumario:Lipid droplets (LDs) store energy-rich fatty acids (FAs), but to harvest them, LDs donate FAs to peroxisomes for oxidation. In this issue, Chang et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902061) identify M1 Spastin as an LD–peroxisome tether that interacts with ESCRT-III components to facilitate lipid exchange between these two organelles.

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